THE SQUALESTATINS, NOVEL INHIBITORS OF SQUALENE SYNTHASE PRODUCED BY A SPECIES OF PHOMA .4. PREPARATION OF FLUORINATED SQUALESTATINS BY DIRECTED BIOSYNTHESIS

被引：21

作者：

CANNELL, RJP

DAWSON, MJ

HALE, RS

HALL, RM

NOBLE, D

LYNN, S

TAYLOR, NL

机构：

[1] GLAXO GRP RES LTD,DEPT PROT BIOCHEM,GREENFORD UB6 0HE,MIDDX,ENGLAND

[2] GLAXO GRP RES LTD,DEPT STRUCT CHEM,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 09期

关键词：

D O I：

10.7164/antibiotics.46.1381

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Feeding of fluorinated benzoic acids to fermentations of a Phoma sp. resulted in the biosynthesis of a series of novel fluorinated squalestatins. The feeding studies, isolation, structural elucidation and biological activities of these compounds are reported.

引用

页码：1381 / 1389

页数：9

共 7 条

[1]

CAMM EL, 1977, PROGR PHYTOCHEMISTRY, V4, P169

[2] THE SQUALESTATINS, NOVEL INHIBITORS OF SQUALENE SYNTHASE PRODUCED BY A SPECIES OF PHOMA .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITY [J].