REPEATED ADMINISTRATION OF LISURIDE DOWN-REGULATES DOPAMINE-D-2 RECEPTOR FUNCTION IN MESOSTRIATAL AND IN MESOLIMBOCORTICAL RAT-BRAIN REGIONS

被引：14

作者：

NISOLI, E ^{[1
]}

MEMO, M ^{[1
]}

MISSALE, C ^{[1
]}

CARRUBA, MO ^{[1
]}

SPANO, P ^{[1
]}

机构：

[1] UNIV BRESCIA,SCH MED,INST PHARMACOL & EXPTL THERAPEUT,VIA VALSABBINA 19,I-25124 BRESCIA,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 176卷 / 01期

关键词：

Adenylate cyclase activity; Bromocriptine; Dopamine receptors; Lisurides; Neuronal plasticity; SK&F 82526;

D O I：

10.1016/0014-2999(90)90135-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of lisuride, a DA agonist that acts selectively on D-2 DA receptors were studied. The functional state of D-1 and D-2 DA receptors was evaluated from measurements of SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated daily for 26 days with saline or lisuride (100 μg/kg i.p.). Persistent stimulation by lisuride of DA receptors in striatum, nucleus accumbens, substantia nigra, frontal cortex, hippocampus and pituitary gland induced a down-regulation of D-2 receptors without changing the functional activity of D-1 receptors. © 1990.

引用

页码：85 / 90

页数：6

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