SUCCESSFUL TREATMENT OF AUTO-IMMUNE DISEASE IN (NZB-NZW)F1 FEMALE MICE BY USING FRACTIONATED TOTAL LYMPHOID IRRADIATION

被引：39

作者：

SLAVIN, S

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 10期

关键词：

D O I：

10.1073/pnas.76.10.5274

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adult female (NZB/NZW)F1 hybrid mice with documented autoimmune glomerulonephritis resembling systemic lupus erythematosus were treated with fractionated total lymphoid irradiation (TLI), a modification of the radiotherapeutic regimen currently used for the treatment of Hodgkin disease. After TLI, proteinuria subsided in all mice that had undergone radiotherapy, and the mean survival increased from 359 days in untreated controls to 545 days. It is suggested that TLI should be further investigated as a new approach for immunoregulation of autoimmune disorders.

引用

页码：5274 / 5276

页数：3

共 22 条

[1] LONG-TERM EFFECTS OF RADIATION ON T-LYMPHOCYTES AND B-LYMPHOCYTES IN PERIPHERAL-BLOOD OF PATIENTS WITH HODGKINS-DISEASE [J].