ACUTE AND CHRONIC DESIPRAMINE TREATMENT EFFECTS ON REWARDING ELECTRICAL-STIMULATION OF THE LATERAL HYPOTHALAMUS

被引:20
作者
HALL, FS [1 ]
STELLAR, JR [1 ]
KELLEY, AE [1 ]
机构
[1] HARVARD UNIV,DEPT PSYCHOL & SOCIAL RELAT,CAMBRIDGE,MA 02138
关键词
Desipramine; Dopamine; Self-stimulation reward;
D O I
10.1016/0091-3057(90)90334-E
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Two weeks of chronic desipramine HCl (DMI) (10 mg/kg, IP) treatment did not alter reward or motor/performance components of intracranial self-stimulation (ICSS) as assessed with the rate-frequency method. Acute DMI treatment produced an ICSS reward decrement relative to saline control treatment, which was similar in size on Day 1 and Day 15 of chronic testing. The failure to find a chronic DMI effect on ICSS reward suggests that ICSS in normal rats may not be a valid animal model of depression. A better paradigm may be to test the ability of antidepressants to reverse a chronic reduction in ICSS reward function that is first produced by some other method. © 1990.
引用
收藏
页码:277 / 281
页数:5
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