ELEVATED SODIUM-LITHIUM COUNTERTRANSPORT - A FAMILIAL MARKER OF HYPERLIPEMIA AND HYPERTENSION

被引:76
作者
CARR, SJ
THOMAS, TH
LAKER, MF
WILKINSON, R
机构
[1] FREEMAN RD HOSP,DEPT NEPHROL,FREEMAN RD,NEWCASTLE TYNE NE7 7DN,TYNE & WEAR,ENGLAND
[2] ROYAL VICTORIA INFIRM,DEPT MED,NEWCASTLE TYNE,ENGLAND
[3] FREEMAN RD HOSP,DEPT MED,NEWCASTLE TYNE NE7 7DN,TYNE & WEAR,ENGLAND
关键词
Essential hypertension; Hyperlipidaemia; Sodium-lithium countertransport;
D O I
10.1097/00004872-199002000-00007
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Erythrocyte sodium-lithium countertransport was measured in normolipidaemic and hyperlipidaemic hypertensive patients, hyperlipidaemic normotensive patients and normal controls. Hypertension and hyperlipidaemia were each independently associated with raised sodium-lithium countertransport (by analysis of variance, P < 0.01 and P < 0.01). The effects were additive so that hyperlipidaemia could not explain raised sodium-lithium countertransport in hypertension. In hyperlipidaemic hypertensive patients, levels of plasma cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and very-low-density lipoprotein (VLDL) cholesterol were increased, and high-density lipoprotein (HDL) cholesterol was reduced. Of these patients, 73.3% had a known family history of hypertension. Their normotensive first degree relatives were studied, and 48% of these also had raised sodium-lithium countertransport and abnormal plasma lipids (raised cholesterol, triglycerides and LDL cholesterol, and reduced HDL cholesterol). Relatives with normal sodium-lithium countertransport had normal lipids. Therefore, raised sodium—lithium countertransport was associated with the inheritance of both hypertension and hyperlipidaemia, and this could explain why raised sodium-lithium countertransport has been associated with a family history of both hypertension and associated cardiovascular disease. © Current Science Ltd.
引用
收藏
页码:139 / 146
页数:8
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