STEREOCONTROLLED SYNTHESIS OF (2S,3S,8S,9S)-3-AMINO-9-METHOXY-2,6,8-TRIMETHYL-10-PHENYLDECA-4E,6E-DIENOIC ACID (ADDA) THE CHARACTERISTIC AMINO-ACID OF MICROCYSTINS AND NODULARIN

被引：9

作者：

BEATTY, MF

JENNINGSWHITE, C

AVERY, MA

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 06期

关键词：

D O I：

10.1039/c39910000351

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(4R,5S)-4-Methyl-5-phenyloxazolidin-2-one was used as a chiral template to construct the 8S and 9S chiral centres of (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid (ADDA), the 2S and 3S centres were derived from D-aspartic acid.

引用

页码：351 / 352

页数：2

共 5 条

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[2] STEREOSELECTIVE REACTIONS OF CHIRAL ENOLATES - APPLICATION TO THE SYNTHESIS OF (+)-PRELOG-DJERASSI LACTONIC ACID
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[3] KONST H, 1965, CAN J COMP MED VET S, V29, P221
[4] NODULARIN, MICROCYSTIN, AND THE CONFIGURATION OF ADDA
RINEHART, KL
HARADA, K
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CHEN, C
HARVIS, CA
MUNRO, MHG
BLUNT, JW
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[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (25) : 8557 - 8558
[5] RINEHART KL, 1989, TETRAHEDRON LETT, V30, P4349

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