REACTIONS OF POLYFLUOROCARBONYL COMPOUNDS WITH 1,3,3-TRIMETHYL-3,4-DIHYDROISOQUINOLINE AND ITS DERIVATIVES

被引：13

作者：

SVIRIDOV, VD

CHKANIKOV, ND

GALAKHOV, MV

SHKLYAEV, YV

SHKLYAEV, VS

ALEKSANDROV, BB

GAVRILOV, MS

机构：

[1] A. N. Nesmeyanov Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, Moscow

来源：

BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR DIVISION OF CHEMICAL SCIENCE | 1990年 / 39卷 / 06期

关键词：

D O I：

10.1007/BF00962396

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1,3,3-Trimethyl-3,4-dihydroisoquinolines, which exist in the imine form, undergo C-hydroxyalkylation upon reaction with hexafluoroacetone and esters of trifluoropyruvic acid at the C1-CH3 group at 20-degrees-C. The products with the ketoesters are converted upon heating to gamma-lactams. Derivatives of 1,3,3-trimethyl-3,4-dihydroisoquinoline substituted at C1-CH3 group and existing in the enamine form, react with esters of trifluoropyruvic acid at 20-degrees-C to give exclusively gamma-lactams and do not give reaction products with hexafluoroacetone.

引用

页码：1268 / 1272

页数：5