18-SUBSTITUTED STEROIDS .4. CHEMICAL SYNTHESIS OF 3-ALPHA,18,21-TRIHYDROXY-5-BETA-PREGNAN-20-ONE 18-]20-HEMIACETAL (18-HYDROXY-TETRAHYDRO-DOC)

被引：4

作者：

HOSSAIN, M

KIRK, DN

机构：

[1] Medical Research Council Steroid Reference Collection, Chemistry Department, Westfield College, Hampstead, London

来源：

STEROIDS | 1979年 / 34卷

关键词：

D O I：

10.1016/0039-128X(79)90137-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3α, 18, 21-Trihydroxy-5β-pregnan-20-one 18 → 20-hemiacetal (18-hydroxy-tetrahydro-DOC) has been prepared from 3α-acetoxy-5β-pregnan-20-one by reduction to the 20β-alcohol, application of the 'hypoiodite' reaction [Pb(OAc)4-I2-hv] with subsequent steps leading to the 18-hydroxy-20-ketone (as hemiacetal), and C-21 acetoxylation [Pb(OAc)4] followed by hydrolysis. © 1979.

引用

页码：677 / 681

页数：5

共 8 条

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