ANTIBODIES TO VASCULAR HEPARAN-SULFATE PROTEOGLYCAN IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：33

作者：

FILLIT, H

LAHITA, R

机构：

[1] Department of Geriatrics and Adult Development, The Mount Sinai Medical Center, Mount Sinai, NY

[2] Division of Rheumalology, St. Luke's-Rooseveli Hospital, St. Luke, NY

来源：

AUTOIMMUNITY | 1991年 / 9卷 / 02期

关键词：

D O I：

10.3109/08916939109006752

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic lupus erythemdtosus (SLE) is an autoimmune disease which involves the basement membranes of blood vessels in multiple organs. An important component of the microvasculature is vascular heparan sulfate proteoglycan (HSPG). In this study, we investigated the presence in SLE and other immune disease sera of autoantibodies to purified vascular HSPG. Our data demonstrate that antibody to HSPG is found primarily in SLE sera, and not in sera from controls or patients with other immune diseases. The titer of antibody to HSPG correlated with complement depletion in SLE sera. Antibody to HSPG was frequently found in high titer in SLE patients with renal and neurologic involvement. These studies indicate that our assay for antibody to vascular HSPG detects a pathologically relevant autoantibody in SLE sera. The implications of our findings for pathogenesis of vascular autoimmunity are discussed, including the relationship of anti-vascular HSPG antibody to anti-DNA and antiphospholipid antibodies. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：159 / 164

页数：6

共 41 条

[1] Klemperer P.A.D., Baehr G., Diffuse collagen disease, J. Amer Med Assoc, 119, pp. 331-332, (1942)
[2] Theofilopoulos A.N., Prud'homrne G.J., Dixon F.J., Autoimmune aspects of systemic lupus erythematosus, Autoimmunity: basic concepts
[3] systemic and selected organspecific diseases, pp. 190-218, (1985)
[4] Schwartz R.S., Stollar B.D., Origins of anti-DNA antibodies, J Clin Invest, 15, (1985)
[5] Harris E.N., Asherson R.A., Hughes G.R.V., Antiphospholipid antibodies-autoantibodies with a difference, Ann Rev Med, 39, pp. 261-271, (1988)
[6] Winfield J.B., Faiferman I., Kiffler D., Avidity of anti-DNA antibodies in serum and IgG glornerular eluates from patients with systemic lupus erythematosus, J Clin Invest, 59, pp. 90-96, (1977)
[7] Faaber P., Capel P.J., Rikje P.M., Vierwinden G., Van de Putte L.B.A., Koene R.A.P., Cross reactivity of anti-DNA antibodies with proteoglycans, Clin Exp Immunol, 55, pp. 502-508, (1984)
[8] Wight T.N., Cell biology of arterial proteoglycans, Arteriosclerosis, 9, pp. 1-20, (1988)
[9] Shimada K., Ozawa T., Evidence that cell surface heparan sulfate is involved in the high affinity thrombin binding to cultured porcine aortic endothelial cells, J Clin Invest, 75, pp. 1308-1316, (1985)
[10] Marcum J.A., Atha D.H., Fritze L.M.S., Nawroth P., Stern D., Rosenberg R.D.R., Cloned bovine aortic endothelial cells synthesized anticoagulantly active heparan sulfate proteoglycan, J Biol Chem, 261, pp. 7507-7517, (1986)

← 1 2 3 4 5 →