ELEVATED SERUM MANGANESE SUPEROXIDE-DISMUTASE IN ACUTE LEUKEMIAS

被引：37

作者：

NISHIURA, T

SUZUKI, K

KAWAGUCHI, T

NAKAO, H

KAWAMURA, N

TANIGUCHI, M

KANAYAMA, Y

YONEZAWA, T

TANIGUCHI, N

机构：

[1] OSAKA UNIV,SCH MED,DEPT BIOCHEM,2-2 YAMADAOKA,SUITA,OSAKA 565,JAPAN

[2] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 2,OSAKA,JAPAN

[3] UBE IND LTD,UBE RES LAB,UBE,JAPAN

[4] KUCCHAN KOUSEI HOSP,HOKKAIDO,JAPAN

[5] TEKOKU WOMENS COLL,DEPT CHILD EDUC,OSAKA,JAPAN

来源：

CANCER LETTERS | 1992年 / 62卷 / 03期

关键词：

ACUTE MYELOID LEUKEMIA; ACUTE LYMPHOID LEUKEMIA; MANGANESE-SUPEROXIDEDISMUTASE;

D O I：

10.1016/0304-3835(92)90098-G

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We measured the serum levels of manganese-superoxide dismutase (Mn-SOD) in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Serum Mn-SOD level for normal subjects was 94.1 +/- 23.5 ng/ml (mean +/- S.D.), the levels for AML and ALL patients were 159.6 +/- 77.1 ng/ml and 154.4 +/- 77.0 ng/ml, respectively. The serum Mn-SOD levels were unrelated to individual intracellular Mn-SOD levels, but correlated well with serum lactate dehydrogenase values. Regression of the leukemia was accompanied by decrease in the serum level of Mn-SOD. Serum Mn-SOD may thus serve as a measure of the activity of the disease.

引用

页码：211 / 215

页数：5

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