REGIONAL DIFFERENCES IN THE DOPAMINERGIC REGULATION OF CYCLIC-AMP FORMATION WITHIN THE RAT NUCLEUS-ACCUMBENS - COMPARISON WITH THE STRIATAL COMPLEX OF THE LIZARD GEKKO-GECKO

被引：1

作者：

HENSELMANS, JML

HEYNA, MH

STOOF, JC

机构：

[1] FREE UNIV AMSTERDAM,FAC MED,DEPT NEUROL,NEUROSCI RES INST,GRAD SCH NEUROSCI AMSTERDAM,1081 BT AMSTERDAM,NETHERLANDS

[2] FREE UNIV AMSTERDAM,FAC MED,DEPT PHARMACOL,1081 BT AMSTERDAM,NETHERLANDS

[3] FREE UNIV AMSTERDAM,FAC MED,DEPT ANAT,1081 BT AMSTERDAM,NETHERLANDS

来源：

NEUROSCIENCE LETTERS | 1993年 / 158卷 / 01期

关键词：

DOPAMINE; NUCLEUS ACCUMBENS; CAMP;

D O I：

10.1016/0304-3940(93)90617-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of dopamine D2 receptor activation on the forskolin or D1 receptor stimulated formation of cyclic adenosine monophosphate (cyclic AMP) were investigated in tissue slices of two subregions of the rat nucleus accumbens and in the striatal complex of a lizard. Cyclic AMP production in the tissue was estimated by measuring the conversion of [H-3]adenine in a superfusion system. Activation of a D2 receptor appeared to inhibit the D1 receptor agonists or forskolin stimulated formation of cAMP in the rostrolateral, but not in the caudomedial part of the rat nucleus accumbens. In the striatal complex of the lizard the formation of cAMP was dramatically stimulated by forskolin, but only marginally by dopamine. Neither the forskolin, nor the dopamine stimulated cyclic AMP formation could be inhibited by activation of D2 receptors. These findings are compatible with previously obtained functional data indicating that especially the caudomedial part of the rat nucleus accumbens has much in common with the striatal complex of the lizard.

引用

页码：79 / 82

页数：4

共 21 条

[1] THE DOPAMINE-D2 RECEPTOR - 2 MOLECULAR-FORMS GENERATED BY ALTERNATIVE SPLICING [J].

DALTOSO, R ;

SOMMER, B ;

EWERT, M ;

HERB, A ;

PRITCHETT, DB ;

BACH, A ;

SHIVERS, BD ;

SEEBURG, PH .

EMBO JOURNAL, 1989, 8 (13) :4025-4034

[2] ONTOGENY OF MU-OPIOID, DELTA-OPIOID AND KAPPA-OPIOID RECEPTORS MEDIATING INHIBITION OF NEUROTRANSMITTER RELEASE AND ADENYLATE-CYCLASE ACTIVITY IN RAT-BRAIN [J].

DEVRIES, TJ ;

HOGENBOOM, F ;

MULDER, AH ;

SCHOFFELMEER, ANM .

DEVELOPMENTAL BRAIN RESEARCH, 1990, 54 (01) :63-69

[3] STIMULATION OF D-2 DOPAMINE-RECEPTORS DECREASES THE EVOKED INVITRO RELEASE OF [H-3]ACETYLCHOLINE FROM RAT NEOSTRIATUM - ROLE OF K+ AND CA-2+ [J].

DRUKARCH, B ;

SCHEPENS, E ;

SCHOFFELMEER, ANM ;

STOOF, JC .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (06) :1680-1685

[4] SINGLE K+ CHANNELS ACTIVATED BY D2-DOPAMINE RECEPTORS IN ACUTELY DISSOCIATED NEURONS FROM RAT CORPUS STRIATUM [J].

FREEDMAN, JE ;

WEIGHT, FF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (10) :3618-3622

[5] AFFERENT CONNECTIONS OF THE STRIATUM AND THE NUCLEUS-ACCUMBENS IN THE LIZARD GEKKO-GECKO [J].

GONZALEZ, A ;

RUSSCHEN, FT ;

LOHMAN, AHM .

BRAIN BEHAVIOR AND EVOLUTION, 1990, 36 (01) :39-58

[6]

GROENEWEGEN HJ, 1990, FUNCTIONAL ANATOMY V, P19

[7] DIFFERENCES IN THE REGULATION OF ACETYLCHOLINE-RELEASE UPON D2 DOPAMINE AND N-METHYL-D-ASPARTATE RECEPTOR ACTIVATION BETWEEN THE STRIATAL COMPLEX OF REPTILES AND THE NEOSTRIATUM OF RATS [J].

HENSELMANS, JML ;

HOOGLAND, PV ;

STOOF, JC .

BRAIN RESEARCH, 1991, 566 (1-2) :8-12

[8] REGIONAL DIFFERENCES IN THE REGULATION OF ACETYLCHOLINE-RELEASE UPON D2 DOPAMINE AND N-METHYL-D-ASPARTATE RECEPTOR ACTIVATION IN RAT NUCLEUS-ACCUMBENS AND NEOSTRIATUM [J].

HENSELMANS, JML ;

STOOF, JC .

BRAIN RESEARCH, 1991, 566 (1-2) :1-7

[9]

HOOGLAND PV, 1989, J COMP NEUROL, V253, P46

[10]

KELLY E, 1987, N-S ARCH PHARMACOL, V335, P508

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