MECHANISM OF CARCINOGENESIS WITH 1-ARYL-3,3-DIALKYLTRIAZENES . ENZYMATIC DEALKYLATION BY RAT LIVER MICROSOMAL FRACTION IN VITRO

被引:129
作者
PREUSSMA.R
VONHODEN.A
HENGY, H
机构
[1] Forschergruppe Praeventivmedizin am Max-Planck-Institut fur Immunbiologie, Freiburg/Br.
关键词
D O I
10.1016/0006-2952(69)90002-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
16 Aryl-dialkyltriazenes have been investigated as substrates for N-dealkylation by microsomal fraction from rat liver in vitro. The potent carcinogens 1-phenyl-3, 3-dimethyltriazene (I), 1-(pyridyl-3)-3,3-dimethyltriazene (II) and several other triazenes were oxydatively dealkylated to form the corresponding aldehyde. In the case of (I) aniline was also shown to be formed as metabolite. The results suggest that carcinogenic aryldialkyltriazenes are dealkylated to form aryl-monoalkyltriazenes as proximate carcinogens. Arylmonoalkyltriazenes are known alkylating agents and carcinogenic activity of triazenes can best be explained by alkylation of biopolymers. A mechanism of action is proposed. © 1969.
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