FUNCTIONAL-SIGNIFICANCE OF THE DORSAL RESPIRATORY GROUP IN ADULT AND NEWBORN RATS - INVIVO AND INVITRO STUDIES

被引:61
作者
HILAIRE, G
MONTEAU, R
GAUTHIER, P
REGA, P
MORIN, D
机构
[1] Département de Physiologie et Neurophysiologie, Equipe Biologie des Rythmes et du Développement, Faculté des Sciences et Techniques St. Jérôme, Marseilles
关键词
Dorsal respiratory group; In vitro; Newborn; Rat; Respiration;
D O I
10.1016/0304-3940(90)90357-F
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The involvement of the dorsal part of the medulla (the so-called dorsal respiratory group: DRG) in the networks participating in respiratory function was investigated in newborn (in vitro) and adult (in vivo) rats. In the dorsal part of the medulla of the isolated brainstem of newborn rats, no respiratory neurons were found and stimulations or lesions neither modified nor suppressed the respiratory output. On the contrary, similar experiments suggest that sites in the ventral medulla have a fundamental importance for respiration. In adult rats, lesion of the DRG areas by electrocoagulation induced transient changes in respiratory timing, and resulted in a significant decrease in the amplitude of the contralateral phrenic output. These results suggest that the dorsal part of the medulla is not involved in controlling respiratory activity in the newborn rat. In adults, no definite conclusion can be reached, but the functional role of the DRG, if any, is probably restricted. © 1990.
引用
收藏
页码:133 / 138
页数:6
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