PHENYTOIN (DILANTIN)-INDUCED CLEFT-LIP AND PALATE IN A-J MICE - SCANNING AND TRANSMISSION ELECTRON-MICROSCOPIC STUDY

被引:62
作者
SULIK, KK [1 ]
JOHNSTON, MC [1 ]
AMBROSE, LJH [1 ]
DORGAN, D [1 ]
机构
[1] UNIV N CAROLINA,DENT RES CTR,CHAPEL HILL,NC 27514
来源
ANATOMICAL RECORD | 1979年 / 195卷 / 02期
关键词
D O I
10.1002/ar.1091950201
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
High incidences of cleft lip and palate (CLP) Produced by maternal intraperitoneal administration of 75 mg/kg pehnytoin on gestational day 10 to A/J mice are associated with asevere size reduction in the lateral nasal process. Scanning and transmission EM analyses of this region demonstrate a marked change in the morphology of the mesenchymal cells underlying the surface epithelium in treated versus control day 11 (7‐tail somite) embryos: long, branching cellular processes, which form a dense meshwork that appears to interact with the epithelial basement lamina in control embryos are undeveloped or absent in phenytoin‐treated embryos. The ultrastructural morphology of these cell processes is described and their possible importance in normal development is discussed. Scanning EM observations of incomplete clefts of the lip which frequently result from phenytoin treatment indicate that Simonart's bands form from fusionof the lateral and medial nasal processes in association with a lack of fusion of the maxillary process with the medial nasal process. Copyright © 1979 Wiley‐Liss, Inc.
引用
收藏
页码:243 / 255
页数:13
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