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MAPPING OF THE GLYCINE RECEPTOR ALPHA-2-SUBUNIT GENE AND THE GABA-A ALPHA-3-SUBUNIT GENE ON THE MOUSE X-CHROMOSOME

被引：22
作者：
DERRY, JMJ
BARNARD, PJ
机构：
[1] MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, CB2 2QH, Hills Road
来源：
GENOMICS | 1991年 / 10卷 / 03期
关键词：
D O I：
10.1016/0888-7543(91)90441-G
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We have mapped the gene for the α2-subunit of the inhibitory glycine receptor (Glra2) to the telomeric end of the mouse X chromosome by backcross analysis of a Mus musculus/Mus spretus interspecific cross. In addition, we have extended the mapping of the GABAA α3-subunit receptor gene (Gabra3). A deduced gene order of cen-Cybb-Hprt-DXPas6-Gabra3-Rsvp-Gdx/Cf-8-Dmd-Pgk-1-DXPas2-Plp-DXPas1-Glra2-tel places Gabra3 proximal to the visual pigment gene Rsvp and Glra2 in the region of loci for hypophosphatemia (Hyp), steroid sulfatase (Sts), and the E1α-subunit of pyruvate dehydrogenase (Pdha1). This establishes the XF region of the mouse X chromosome as homologous with the Xp22.1-p22.3 region of the human X chromosome and indicates the presence of an evolutionary breakpoint in the region of Xp21.3. © 1991.
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页码：593 / 597
页数：5
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