PHARMACOKINETICS OF PREDNISOLONE IN CHILDREN WITH THE NEPHROTIC SYNDROME

被引：20

作者：

ROSTIN, M ^{[1
]}

BARTHE, P ^{[1
]}

HOUIN, G ^{[1
]}

ALVINERIE, M ^{[1
]}

BOUISSOU, F ^{[1
]}

机构：

[1] CHU TOULOUSE PURPAN,UNITE NEPHROL PEDIAT,F-31059 TOULOUSE,FRANCE

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 05期

关键词：

PREDNISOLONE; NEPHROTIC SYNDROME; PHARMACOKINETICS; PLASMA ALBUMIN; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY;

D O I：

10.1007/BF00869822

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The aim of this study was to establish whether the criteria for the clinical effectiveness of steroids are correlated with the pharmacokinetics of prednisolone in children treated with prednisone during an attack of idiopathic nephrotic syndrome (INS). Thirteen patients with nephrosis were included. Prednisolone, prednisone and cortisol levels were measured using a specific high-performance liquid chromatography assay after an oral dose of 1 mg/kg body weight of prednisone taken at the onset of the disease. All the pharmacokinetic parameters, including the conversion of prednisone to prednisolone were similar to the data already published in children with INS. No correlation was found between the values of pharmacokinetic parameters and criteria of clinical effectiveness. Hypo-albuminaemia was significantly correlated with the area under the plasma-concentration curve but not with the elimination half-life of prednisolone. Moreover, the prednisolone elimination half-life correlated with the urinary excretion of 17-hydroxycorticosteroids achieved in the first 6 h. The present study suggests that routine measurements of prednisolone kinetics do not help when assessing the treatment of children with INS.

引用

页码：470 / 473

页数：4

共 18 条

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