NEW 5-NITROIMIDAZOLES BEARING LACTAME NUCLEUS - SYNTHESIS AND ANTIBACTERIAL PROPERTIES

被引：40

作者：

JENTZER, O

VANELLE, P

CROZET, MP

MALDONADO, J

BARREAU, M

机构：

[1] FAC PHARM MARSEILLE,CHIM ORGAN LAB,27 BD JEAN MOULIN,F-13385 MARSEILLE 5,FRANCE

[2] RHONE POULENC RORER CTR RECH VITRY,F-94403 VITRY,FRANCE

[3] FAC SCI & TECH ST JEROME,CHIM ORGAN LAB B,CNRS,URA 1412,F-13397 MARSEILLE 13,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 26卷 / 07期

关键词：

5-NITROIMIDAZOLES; SRN1; REACTION; LACTAMS; ANTIBACTERIAL AGENTS; ANTIANAEROBIC ACTIVITY;

D O I：

10.1016/0223-5234(91)90118-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New 5-nitroimidazoles bearing a trisubstituted ethylenic double bond in position 2 were prepared by reacting various 1-alkyl-2-chloromethyl-5-nitroimidazole with 3-nitrolactam anions by S(RN)1 mechanism in phase-transfer catalysis conditions. These compounds showed in vitro and in vivo antianaerobic activity which was clearly greater than that of metronidazole. Structure-activity relationships have been discussed.

引用

页码：687 / 697

页数：11

共 29 条

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