GENETIC RESEARCH IN EMBRYOLOGY

被引：1

作者：

SCHMUTZLER, RK

机构：

[1] University Women’s Hospital, Rheinische Friedrich Wilhelms University Bonn, FRG

来源：

HUMAN REPRODUCTION | 1992年 / 7卷

关键词：

D O I：

10.1093/humrep/7.suppl_1.25

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Based on findings on the molecular mechanisms of differentiation in drosophila, developmental genes have been identified in mammals similar to those in drosophila. Moreover, sequence similarities between drosophila developmental genes and mammalian growth factors provide evidence for common ancestors of such genes and suggest a complex link between growth and differentiation. As numerous oncogenes display their action as growth factors and are expressed during embryogenesis, differentiation and oncogenesis seem to be two sides of the same coin. Therefore, the aim of molecular embryology is twofold; elucidating differentiation processes and disclosing oncogenesis by studying the physiological function of oncogenes during development. Recent progress in molecular genetic technology now allows gene function to be studied by modification or disruption of genes. Models of clinical diseases have already evolved from such work and it is anticipated that progress in molecular embryology will further stimulate work on the diagnosis and therapy of genetic diseases as well as clinical oncology.

引用

页码：25 / 29

页数：5

共 43 条

[1]

Acampora D., D' Esposito M., Faiella A., Migliaccio E., Morelli F., Stomaiuolo A., Nigro V., Simeone A., Boncinelli E., The human HOX gene family, Nucleic Acids Reseasrch, 17, pp. 10385-10402, (1989)

[2]

Austin C.R., Short R.V., Reproduction in Mammals, Book, (1972)

[3]

Bradbury M.W., Isola L.M., Gordon J.W., Enzymatic amplification of a Y chromosome repeat in a single blastomere allows identification of the sex of preimplantation mouse embryos, Proc. Natl. Acad. Sci, 87, pp. 1-5, (1990)

[4]

Chisaka O., Capecchi M.R., Regionally restricted develop¬ mental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5, Nature, 350, pp. 473-478, (1991)

[5]

Gaunt S.J., Sharpe P.T., Duboule D., Spatially restricted domains of homeo-gene transcripts in mouse embryos: Relation to a segmented body plan, Development, 104 Supply, pp. 1-11, (1988)

[6]

Gehring W.J., Homeoboxes in the study of development, Science, 236, pp. 1245-1252, (1987)

[7]

Gehring W., Nothiger R., The Imaginal Discs of Drosophila in Developmental Systems: Insects, 2, pp. 221-290, (1973)

[8]

Hall J.G., Genomic imprinting: Review and relevance to human diseases, Am. J. Hum. Genet, 46, pp. 857-873, (1990)

[9]

Hall S.H., Joseph D.R., French F.S., Conti M., Follicle- stimulating hormone induces transient expression of the proto¬ oncogene c-fos in primary sertoli cell cultures, Mol. Endocrinol., 56, pp. 55-61, (1988)

[10]

Handyside A.H., Kontogianni E.H., Hardy K., Winston R.M.L., Pregnancies from biopsed human preimplantation embryos sexed by Y-specific DNA amplification, Nature, 344, pp. 768-770, (1990)

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