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CALCIUM CALMODULIN-DEPENDENT PROTEIN-KINASE-II AND PROTEIN PHOSPHATASE 2B (CALCINEURIN) IMMUNOREACTIVITY IN THE RAT HIPPOCAMPUS LONG AFTER ISCHEMIA

被引：10
作者：
ONODERA, H
YAMASAKI, Y
KOGURE, K
MIYAMOTO, E
机构：
[1] TOHOKU UNIV,SCH MED,INST BRAIN DIS,DEPT NEUROL,SENDAI,MIYAGI 980,JAPAN
[2] KUMAMOTO UNIV,SCH MED,DEPT PHARMACOL,KUMAMOTO 860,JAPAN
来源：
BRAIN RESEARCH | 1995年 / 684卷 / 01期
关键词：
CEREBRAL ISCHEMIA; CA2+/CALMODULIN DEPENDENT PROTEIN KINASE II; CALCINEURIN; HIPPOCAMPUS; SYNAPTIC PLASTICITY;
D O I：
10.1016/0006-8993(95)00382-Z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Calcium/calmodulin-dependent protein kinase II (kinase II) and protein phosphatase 2B (calcineurin) immunoreactivity in the rat hippocampus was studied 100 days after ischemic damage to hippocampal CA1 pyramidal neurons. One-hundred days after ischemia, only a few CAI. pyramidal neurons survived and they exhibited enhanced kinase II and calcineurin immunoreactivity in their basal and apical dendrites. The stratum lucidum of the CA3 (messy fiber terminal area) had enhanced kinase II and calcineurin immunoreactivity. These results suggest activity-dependent regulation and redistribution of kinase II and calcineurin after intervention in neuronal circuitry.
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页码：95 / 98
页数：4
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