SIMULTANEOUS 51CR EDETIC ACID INULIN AND ENDOGENOUS CREATININE CLEARANCES IN 20 PATIENTS WITH RENAL DISEASE

Experiments in dogs have shown that the clearance of 51Cr edetic acid remains identical with the simultaneous clearance of inulin, and that it is independent of the concentration of Cr edetic acid in the plasma. Simultaneous 51Cr edetic acid, inulin, and endogenous creatinine clearances were measured in 20 patients with renal disease of various origin and a wide range of severity. The correlation between 51Cr edetic acid and inulin clearances (r=0.992) was found to be better than the correlation between creatinine and inulin clearances (r=0.908). 51Cr edetic acid is safe and convenient to use. © 1968, British Medical Journal Publishing Group. All rights reserved.