EFFECT OF DIAZEPAM AND CHLORDIAZEPOXIDE ON METABOLISM OF OTHER DRUGS

被引：30

作者：

JORI, A

PRESTINI, PE

PUGLIATTI, C

机构：

[1] Instituto di Ricerche Farmacologische “Mario Negri”, Milan, 20157, Via Eritrea

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1969年 / 21卷 / 06期

关键词：

D O I：

10.1111/j.2042-7158.1969.tb08272.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diazepam and chlordiazepoxide, even at high single doses, do not inhibit the metabolic transformation of p‐nitroanisol, aniline and aminopyrine by the 9,000 g fraction of rat liver. Although diazepam and chlordiazepoxide increase the sleeping time induced by pentobarbitone, this effect is not explained by an increase in the brain level of pentobarbitone. Repeated administrations of the two benzodiazepines increase the metabolism of p‐nitroanisol, aniline, amidopyrine and shorten the sleeping time induced by pentobarbitone in rats. There was a concomitant reduction of the concentration of brain pentobarbitone. 1969 Royal Pharmaceutical Society of Great Britain

引用

页码：387 / +

页数：1

共 8 条

[1]

BRODIE BB, 1953, J PHARMACOL EXP THER, V109, P26

[2]

CONNEY AH, 1967, PHARMACOL REV, V19, P317

[3]

GARATTINI S, 1967, ADVANCES PHARMACO ED, V5, P213

[4]

Gilbert D, 1965, Food Cosmet Toxicol, V3, P417, DOI 10.1016/S0015-6264(65)80129-8