MECHANISM OF ERYTHROCYTE LYSIS BY LYSOPHOSPHATIDYLCHOLINE

被引：64

作者：

BIERBAUM, TJ ^{[1
]}

BOUMA, SR ^{[1
]}

HUESTIS, WH ^{[1
]}

机构：

[1] STANFORD UNIV, DEPT CHEM, STANFORD, CA 94305 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 555卷 / 01期

基金：

美国国家卫生研究院;

关键词：

(Erythrocyte membrane); Hemolysis; Lysophosphatidylcholine; Na[!sup]+[!/sup] channel; Tetrodotoxin;

D O I：

10.1016/0005-2736(79)90075-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysophosphatidylcholine micelles liberated several cell surfcae polypeptides from erythrocyte membranes, inducing a Na-selective permeability defect which lead to colloid osmotic lysis. Evidence supports the hypothesis that at the lowest lytic lysophospholipid concentrations, selective disruption of membrane protein function, rather than gross structural reorganization of the membrane, is the primary lytic mechanism.

引用

页码：102 / 110

页数：9

共 16 条

[1] BOUMA SR, 1977, J BIOL CHEM, V252, P6759
[2] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY
ELLMAN, GL
COURTNEY, KD
ANDRES, V
FEATHERSTONE, RM
[J]. BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) : 88 - &
[3] GRIEG ME, 1956, ARCH BIOCHEM BIOPHYS, V61, P335
[4] HABERLAND ME, 1975, J BIOL CHEM, V250, P6636
[5] Hille B., 1970, Progr. Biophys. molec. Biol., V21, P1, DOI 10.1016/0079-6107(70)90022-2
[6] HUESTIS WH, 1977, J BIOL CHEM, V252, P6764
[7] ROLE OF LYSOPHOSPHATIDES + FATTY ACIDS IN HAEMOLYSIS ( CONCEPTUAL REVIEW )
JEANNET, M
HASSIG, A
[J]. VOX SANGUINIS, 1964, 9 (02) : 113 - &
[8] KROPROWSKI H, 1973, METHOD CELL BIOL, V7, P251
[9] STUDIES ON LYSIS OF RED CELLS AND BIMOLECULAR LIPID LEAFLETS BY SYNTHETIC LYSOLECITHINS, LECITHINS AND STRUCTURAL ANALOGS
REMAN, FC
DEMEL, RA
DEGIER, J
VANDEENE.LL
EIBL, H
WESTPHAL, O
[J]. CHEMISTRY AND PHYSICS OF LIPIDS, 1969, 3 (03) : 221 - &
[10] CHANGES IN SHAPE AND OSMOTIC RESISTANCE OF HUMAN ERYTHROCYTES RESULTED FROM CHANGES IN LYSOLECITHIN CONTENT OF MEMBRANES
SATO, T
FUJII, T
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1974, 22 (01) : 152 - 156

← 1 2 →