MICROVASCULAR ALTERATIONS IN ADULT CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS

被引:36
作者
LENOBLE, JLML
SMITH, TL
HUTCHINS, PM
STRUYKERBOUDIER, HAJ
机构
[1] STATE UNIV LIMBURG,DEPT PHARMACOL,POB 616,6200 MD MAASTRICHT,NETHERLANDS
[2] STATE UNIV LIMBURG,DEPT INTERNAL MED,6200 MD MAASTRICHT,NETHERLANDS
[3] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PHYSIOL & PHARMACOL,WINSTON SALEM,NC 27103
关键词
Essential hypertension; Microcirculation; Muscle; Myogenic tone; Spontaneously hypertensive rats; Vascular resistance;
D O I
10.1161/01.HYP.15.4.415
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The dorsal skin flap technique was used to study skeletal muscle microcirculation in conscious 10-12-week-old spontaneously hypertensive rats and normotensive Wistar-Kyoto control rats. Videorecordings were made for off-line analysis of consecutive segments of the vascular bed. Resting diameters were significantly smaller in spontaneously hypertensive rats than in Wistar-Kyoto rats at the first-order (-28%) and second-order arteriolar (-21%) levels. Precapillary third-order and fourth-order arterioles of spontaneously hypertensive rats had normal diameters, whereas postcapillary small venule diameters were slightly larger in spontaneously hypertensive rats. Thirty percent and 41% of the spontaneously hypertensive rat and Wistar-Kyoto rat third-order arteriolar vessels and 63 and 45% of the fourth-order arteriolar vessels exhibited vasomotion. Vasomotion amplitude, but not frequency, was significantly higher in spontaneously hypertensive rats than in Wistar-Kyoto rats. It is concluded that, in the established phase of spontaneous hypertension in the rat, a decreased diameter of large arterioles is the major mechanism underlying the increased vascular resistance in cutaneous skeletal muscle.
引用
收藏
页码:415 / 419
页数:5
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