LOCALIZATION OF HUMAN ANTIGEN-SPECIFIC HELPER AND SUPPRESSOR FUNCTION IN DISTINCT T-CELL SUB-POPULATIONS

被引:94
作者
HEIJNEN, CJ [1 ]
UYTDEHAAG, F [1 ]
GMELIGMEYLING, FHJ [1 ]
BALLIEUX, RE [1 ]
机构
[1] STATE UNIV UTRECHT HOSP, DEPT CLIN IMMUNOL, UTRECHT, NETHERLANDS
关键词
D O I
10.1016/0008-8749(79)90173-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Distinct human T-cell subpopulations were isolated and cultured in the presence of B-cells and antigens. After an incubation period of 6 days cells were tested for their capacity to secrete antigen-specific antibodies in the PFC-assay. The results indicate that the T-helper activity for the antigen-induced T-dependent B-cell differentiation is located in the Tμ-subpopulation, whereas the suppressor-cell activity is confined to the Tγ-subpopulation. © 1979.
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页码:282 / 292
页数:11
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