PERIPHERAL SEROTONERGIC INHIBITION OF SUCKLING

被引：3

作者：

BATEMAN, ST ^{[1
]}

LICHTMAN, AH ^{[1
]}

CRAMER, CP ^{[1
]}

机构：

[1] DARTMOUTH COLL,DEPT PSYCHOL,HANOVER,NH 03755

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 37卷 / 02期

关键词：

Fenfluramine; Nipple attachment; Quipazine; Serotonin; Weanling rats; Xylamidine;

D O I：

10.1016/0091-3057(90)90324-B

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Systemically administered serotonin, which does not pass the blood-brain barrier, inhibited nipple attachment behavior in 20- and 30-day-old rat pups. Xylamidine, a peripheral serotonin antagonist, attenuated the effects of serotonin, quipazine, and fenfluramine on nipple attachment behavior. Thus, serotonin receptors in the periphery may play an important role in the serotonergic inhibitory mechanism that has been hypothesized as the developing system leading to weaning. However, unlike more general 5-HT antagonists, xylamidine given alone failed to facilitate suckling, suggesting different sites of action for facilitation and inhibition of this infantile behavior. © 1990.

引用

页码：219 / 225

页数：7

共 37 条

[1]

AZIMITIA EC, 1978, HDB PSYCHOPHARMACOLO, V9, P233

[2]

BABICKY A, 1973, PHYSIOL BOHEMOSLOV, V22, P449

[3] EFFECTS OF DL-FENFLURAMINE AND XYLAMIDINE ON GASTRIC-EMPTYING OF MAINTENANCE DIET IN FREELY FEEDING RATS [J].