A LOVE PLATE BIOSENSOR UTILIZING A POLYMER LAYER

被引：129

作者：

GIZELI, E ^{[1
]}

GODDARD, NJ ^{[1
]}

LOWE, CR ^{[1
]}

STEVENSON, AC ^{[1
]}

机构：

[1] PLESSEY RES CASWELL,TOWCESTER NN12 8EQ,NORTHANTS,ENGLAND

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 1992年 / 6卷 / 1-3期

关键词：

D O I：

10.1016/0925-4005(92)80044-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A Love plate device, based on an SSBW piezoelectric substrate coated with a polymer (PMMA) layer, was used to excite a surface guiding shear horizontal wave. The surface mass sensitivity of the device was calculated as a function of the thickness of the polymer layer, using a modelling theory derived for the polymer-Love plate. LB films were used to assess experimentally the surface mass sensitivity and results were compared with theoretical predictions. Investigation of protein interaction with the PMMA surface was performed by following the adsorption of IgG in the range 1-400-mu-g/ml. Finally, the deposition of a protein multilayer, consisted of IgG/anti-IgG and protein A, was clearly detected using the polymer-coated Love plate device.

引用

页码：131 / 137

页数：7

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