SIMULTANEOUS DETERMINATION OF FUROSEMIDE AND AMILORIDE IN PLASMA USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION

被引：33

作者：

REEUWIJK, HJEM ^{[1
]}

TJADEN, UR ^{[1
]}

VANDERGREEF, J ^{[1
]}

机构：

[1] LEIDEN UNIV,CTR BIOPHARMACEUT SCI,DIV ANALYT CHEM,POB 9502,2300 RA LEIDEN,NETHERLANDS

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 575卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80155-J

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic method using fluorescence detection for the simultaneous determination of furosemide and amiloride is described. The chromatographic system is based on reversed-phase ion-pair chromatography with sodium dodecylsulphate as ion-pairing agent. The same counter-ion is used for the ion-pair liquid-liquid extraction to ethyl acetate. The minimum detectable concentration amounts to 0.3 ng of furosemide and 0.03 ng of amiloride per ml of plasma. The applicability of the method is demonstrated by the analysis of plasma samples taken from volunteers receiving both drugs.

引用

页码：269 / 274

页数：6

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