ANALYSES OF 95 1ST-TRIMESTER SPONTANEOUS-ABORTIONS BY CHORIONIC VILLUS SAMPLING AND KARYOTYPE

被引：62

作者：

STROM, CM

GINSBERG, N

APPLEBAUM, M

BOZORGI, N

WHITE, M

CAFFARELLI, M

VERLINSKY, Y

机构：

[1] Department of Obstetrics and Gynecology, Illinois Masonic Medical Center, Reproductive Genetics Institute and Section of Medical Genetics, Chicago, 60657, Illinois

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1992年 / 9卷 / 05期

关键词：

CHORIONIC VILLUS SAMPLING; KARYOTYPE; SPONTANEOUS ABORTIONS; 1ST TRIMESTER;

D O I：

10.1007/BF01204052

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: Our purpose was to determine the incidence of chromosomal aneuploidy in first-trimester pregnancy losses using chorionic villus sampling (CVS). Study Design: All patients presenting for CVS with no fetal cardiac activity were offered CVS. Results: Cytogenetic results were completed in 95 of 96 cases (99%). Eighty-three percent of the karyotypes were aneuploid. The 16 euploid fetuses had no excess of females. Conclusion: CVS is the most reliable method of determining the karyotype of spontaneously aborted fetuses. The incidence of aneuploidy is much greater than in previous reports that analyzed passed products of conception. CVS should be offered to women who present with first-trimester spontaneous abortions.

引用

页码：458 / 461

页数：4

共 16 条

[1] Boue J., Daketse M., Deluchst C., Ravise N., Yvert F., Boue A., Identification par les bandes Q et G des anomalies chromosomiques dans les avortements spontanés, Ann Genet, 19, pp. 233-239, (1976)
[2] Hassold T., Chen N., Funkhouser J., Manuel J.B., Matsuura A., Wilson L., Yamane J.A., Jacobs P.A., A cytogenetic study of 1000 spontaneous abortions, Am Human Genet, 44, pp. 151-178, (1980)
[3] Lauritsen J., Aetiology of spontaneous abortion: A cytogenetic and epidemiological study of 288 abortuses and their parents, Aca Obstet Gynecol Scand Suppl, 52, pp. 1-29, (1986)
[4] Takahara E., Ohama K., Fejiwar A., Cytogenetic study of early spontaneous abortion, Hiroshima J Med Sci, 26, pp. 291-296, (1977)
[5] Warburton D., Stein Z., Kline J., Sesser M., Chromosome abnormalities in spontaneous abortions: Data from a New York City study, Human Embryonic and Fetal Death, pp. 261-288, (1980)
[6] Bartels I., Hansmann I., Eiben B., Excess of females in normal spontaneous abortions, Am J Med Genet, 5, pp. 297-298, (1990)
[7] Hassold T., Quillen S.D., Yamane J.A., Sex rates in spontaneous abortions, Ann Hum Genet, 47, pp. 39-47, (1983)
[8] Creasy, Crolla J.A., Alberman E.D., A cytogenetic study of human spontaneous abortions using banding techniques, Hum Genet, 31, pp. 177-196, (1976)
[9] Kaji T., Ferrier A., Nukawa N., Takahara H., Ohama K., Avirachan S., Anatomic and chromosomal anomalies in 639 spontaneous abortuses, Human Genetics, 55, pp. 87-98, (1980)
[10] Eiben B., Bartels I., Bahr-Porsch S., Borgmann S., Gatz G., Gellert G., Goebel R., Hammans W., Hentemaan M., Osmers R., Rauskolb R., Hansmann I., Cytogenetic analysis of 750 spontaneous abortions with the direct preparation method of chorionic villi and its implications for studying causes of pregnancy wastage, Am J Hum Genet, 47, pp. 656-663, (1990)

← 1 2 →