GLUCOGENOLYTIC AND HYPERGLYCEMIC EFFECT OF 33-49 C-TERMINAL FRAGMENT OF PANCREASTATIN IN THE RAT INVIVO

被引：34

作者：

SANCHEZMARGALET, V ^{[1
]}

CALVO, JR ^{[1
]}

GOBERNA, R ^{[1
]}

机构：

[1] UNIV SEVILLA,FAC MED,DEPT BIOQUIM MED & BIOL MOLEC,AV SANCHEZ PIZJUAN 4,E-41009 SEVILLE,SPAIN

来源：

HORMONE AND METABOLIC RESEARCH | 1992年 / 24卷 / 10期

关键词：

PANCREASTATIN; GLYCOGEN; INSULIN; GLUCAGON; GLUCOSE; RAT;

D O I：

10.1055/s-2007-1003361

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of the 33-49 C-terminal fragment of pancreastatin on glycogen content, glycemia, insulinemia and glucagonemia were studied in the rat in vivo. It was found that after intramesenteric vein injection of the peptide, the glycogen content of liver decreased compared with control group injected with saline-1 < % BSA. Blood glucose levels were increased by the C-terminal fragment of pancreastatin. This study shows that the 33-49 C-terminal fragment of pancreatasin could play a role in glucose metabolism not mediated by insulin or glucagon.

引用

页码：455 / 457

页数：3

共 13 条

[1] PANCREASTATIN INHIBITS INSULIN-SECRETION AND STIMULATES GLUCAGON-SECRETION IN MICE [J].

AHREN, B ;

LINDSKOG, S ;

TATEMOTO, K ;

EFENDIC, S .

DIABETES, 1988, 37 (03) :281-285

[2] PANCREASTATIN AND ISLET HORMONE-RELEASE [J].

EFENDIC, S ;

TATEMOTO, K ;

MUTT, V ;

QUAN, C ;

CHANG, D ;

OSTENSON, CG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7257-7260

[3] PEPTIDE FUNCTION - IS CHROMOGRANIN A PROHORMONE [J].

EIDEN, LE .

NATURE, 1987, 325 (6102) :301-301

[4] BIOACTIVITY OF SYNTHETIC C-TERMINAL FRAGMENT OF RAT PANCREASTATIN ON ENDOCRINE PANCREAS [J].

FUNAKOSHI, A ;

MIYASAKA, K ;

KITANI, K ;

TAMAMURA, H ;

FUNAKOSHI, S ;

YAJIMA, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 158 (03) :844-849

[5]

FUNAKOSHI A, 1989, REGUL PEPTIDES, V6, P225

[6] CHROMOGRANIN-A AND PANCREASTATIN [J].

HUTTNER, WB ;

BENEDUM, UM .

NATURE, 1987, 325 (6102) :305-305

[7] THE MOLECULAR-CLONING OF THE CHROMOGRANIN A-LIKE PRECURSOR OF BETA-GRANIN AND PANCREASTATIN FROM THE ENDOCRINE PANCREAS [J].

HUTTON, JC ;

NIELSEN, E ;

KASTERN, W .

FEBS LETTERS, 1988, 236 (02) :269-274

[8]

IANCANGELO A, 1988, FEBS LETT, V227, P115

[9] CHROMOGRANIN-A - IMMUNOHISTOLOGY REVEALS ITS UNIVERSAL OCCURRENCE IN NORMAL POLYPEPTIDE HORMONE PRODUCING ENDOCRINE GLANDS [J].

OCONNOR, DT ;

BURTON, D ;

DEFTOS, LJ .

LIFE SCIENCES, 1983, 33 (17) :1657-1663

[10]

OSTENSON CG, 1989, ENDOCRINOLOGY, V124, P2986

← 1 2 →