SUPERPARAMAGNETIC IRON-OXIDES AS POSITIVE MR CONTRAST AGENTS - INVITRO AND INVIVO EVIDENCE

被引：171

作者：

CHAMBON, C

CLEMENT, O

LEBLANCHE, A

SCHOUMANCLAEYS, E

FRIJA, G

机构：

[1] Laboratoire Guerbet, 93061 Aulnay-Sous-Bois

[2] Service de Radiologie, Hôpital Laennec, 75007 Paris

来源：

MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 04期

关键词：

IRON; MAGNETIC RESONANCE; CONTRAST ENHANCEMENT; HEART; EXPERIMENTAL STUDY; MR;

D O I：

10.1016/0730-725X(93)90470-X

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The ability of superparamagnetic iron oxides (SPIO) and ultrasmall superparamagnetic iron oxides (USPIO) to act as positive contrast enhancers due to a marked T1 relaxivity was investigated. At low concentrations, an important signal enhancement was observed in vitro, reaching 120% for SPIO and 140% for USPIO in a spin echo 500/22 sequence. The more heavily the sequence was T1-weighted the greater the enhancement. As the concentration increased, the signal dropped. The in vivo study of USPIO in the rat showed that at low doses (14 mumol Fe/kg), the myocardial signal was enhanced by 30%, whereas at high doses (77 mumol Fe/kg), it fell by -50%. These results indicate that in T1-weighted spin echo sequences, the MR signal can be enhanced by low concentrations of superparamagnetic compounds. This effect could be useful in perfusion imaging, and is also important f or a better understanding of any possible paradoxical positive enhancement which could occur in perfused organs.

引用

页码：509 / 519

页数：11

共 11 条

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