UNIVERSAL MAPPING PROBES AND THE ORIGIN OF HUMAN CHROMOSOME-3

被引：52

作者：

HINO, O ^{[1
]}

TESTA, JR ^{[1
]}

BUETOW, KH ^{[1
]}

TAGUCHI, T ^{[1
]}

ZHOU, JY ^{[1
]}

BREMER, M ^{[1
]}

BRUZEL, A ^{[1
]}

YEUNG, R ^{[1
]}

LEVAN, G ^{[1
]}

LEVAN, KK ^{[1
]}

KNUDSON, AG ^{[1
]}

TARTOF, KD ^{[1
]}

机构：

[1] FOX CHASE CANC CTR,INST CANC RES,7701 BURHOLME AVE,PHILADELPHIA,PA 19111

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 02期

关键词：

D O I：

10.1073/pnas.90.2.730

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Universal mapping probes (UMPs) are defined as short segments of human DNA that are useful for physical and genetic mapping in a wide variety of mammals. The most useful UMPs contain a conserved DNA sequence immediately adjoined to a highly polymorphic CA repeat. The conserved region determines physical gene location, whereas the CA repeat facilitates genetic mapping. Both the CA repeat and its neighboring sequence are highly conserved in evolution. This permits molecular, cytogenetic, and genetic mapping of UMPs throughout mammalia. UMPs are significant because they make genetic information cumulative among well-studied species and because they transfer such information from ''map rich'' organisms to those that are ''map poor.'' As a demonstration of the utility of UMPs, comparative maps between human chromosome 3 (HSA3) and the rat genome have been constructed. HSA3 is defined by at least 12 syntenic clusters located on seven different rat chromosomes. These data, together with previous comparative mapping information between human, mouse, and bovine genomes, allow us to propose a distinct evolutionary pathway that connects HSA3 with the chromosomes of rodents, artiodactyls, and primates. The model predicts a parsimonious phylogenetic tree, is readily testable, and will be of considerable use for determining the pathways of mammalian evolution.

引用

页码：730 / 734

页数：5

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