SUPPRESSION OF ANTIBODY-RESPONSES TO RICIN-A CHAIN (RTA) BY MONOCLONAL ANTI-RTA ANTIBODIES

被引：3

作者：

BYERS, VS ^{[1
]}

AUSTIN, EB ^{[1
]}

CLEGG, JA ^{[1
]}

DENTON, G ^{[1
]}

GUNN, B ^{[1
]}

HOOI, D ^{[1
]}

HUDECZ, F ^{[1
]}

PRICE, MR ^{[1
]}

BALDWIN, RW ^{[1
]}

机构：

[1] UNIV NOTTINGHAM, CANC RES CAMPAIGN LABS, NOTTINGHAM NG7 2RD, ENGLAND

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 1993年 / 13卷 / 06期

关键词：

RICIN-A CHAIN; ANTIBODY RESPONSES; IMMUNOREGULATION; MONOCLONAL ANTIBODIES;

D O I：

10.1007/BF00920016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Balb/c mice treated with an immunotoxin constructed by conjugation of murine monoclonal antibody 791T/36 via a disulfide linker to ricin A chain generate a pronounced antibody response to peptide epitopes on ricin A chain. Monoclonal anti-RTA antibodies which recognize peptide epitopes have been developed and these have been used to down-regulate anti-RTA antibody responses in 791T/36-RTA immunotoxin-treated Balb/c mice. Of the five MAB tests, two (608/7 and 596/134) proved most effective, inhibiting anti-RTA antibody formation by up to 73%. MAB treatment was effective when initiated up to 3 days after immunotoxin treatment. Pharmacokinetic studies with 791T/36-RTA have shown that the immunotoxin is rapidly eliminated from the circulation, with no more than 4% remaining in blood after 24 hr. It is proposed that the down-regulation of anti-RTA antibodies is effected by MAB interfering with antigen processing.

引用

页码：406 / 413

页数：8

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