ISOFAGOMINE, A POTENT, NEW GLYCOSIDASE INHIBITOR

被引：174

作者：

JESPERSEN, TM

DONG, WL

SIERKS, MR

SKRYDSTRUP, T

LUNDT, I

BOLS, M

机构：

[1] UNIV MARYLAND,BALTIMORE,MD 21228

[2] TECH UNIV DENMARK,DEPT ORGAN CHEM,DK-2800 LYNGBY,DENMARK

[3] UNIV ORLEANS,BIOCHIM STRUCT LAB,ORLEANS,FRANCE

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 17期

关键词：

D O I：

10.1002/anie.199417781

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Replacing the anomeric C atom of 2‐deoxy‐O‐glucose with an N atom and the ring O atom with a C atom leads to 1, the most potent β‐glycosidase inhibitor known to date. This synthetic monosaccharide derivative also inhibits other glucosidases better than naturally occurring sugar derivatives in which only the O atom in the ring is exchanged for an N atom. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1778 / 1779

页数：2

共 26 条

[1] SIMPLE SYNTHESIS OF (R)-CARNITINE FROM D-GALACTONO-1,4-LACTONE
BOLS, M
LUNDT, I
PEDERSEN, C
[J]. TETRAHEDRON, 1992, 48 (02) : 319 - 324
[2] DUCEP JB, 1990, Patent No. 389723
[3] CONFIGURATIONALLY SELECTIVE TRANSITION-STATE ANALOG INHIBITORS OF GLYCOSIDASES - A STUDY WITH NOJIRITETRAZOLES, A NEW CLASS OF GLYCOSIDASE INHIBITORS
ERMERT, P
VASELLA, A
WEBER, M
RUPITZ, K
WITHERS, SG
[J]. CARBOHYDRATE RESEARCH, 1993, 250 (01) : 113 - 128
[4] THE MECHANISM OF BETA-GLYCOSIDASES - A REASSESSMENT OF SOME SEMINAL PAPERS
FRANCK, RW
[J]. BIOORGANIC CHEMISTRY, 1992, 20 (01) : 77 - 88
[5] MIMICKING THE GLUCOSIDASE TRANSITION-STATE - SHAPE CHARGE CONSIDERATIONS
GANEM, B
PAPANDREOU, G
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (23) : 8984 - 8985
[6] GORMAN J, 1966, METHOD ENZYMOL, V8, P562
[7] Halvorson H., 1966, METHOD ENZYMOL, V8, P559, DOI 10.1016/0076-6879(66)08101-1
[8] CASTANOSPERMINE, A 1,6,7,8-TETRAHYDROXYOCTAHYDROINDOLIZINE ALKALOID, FROM SEEDS OF CASTANOSPERMUM-AUSTRALE
HOHENSCHUTZ, LD
BELL, EA
JEWESS, PJ
LEWORTHY, DP
PRYCE, RJ
ARNOLD, E
CLARDY, J
[J]. PHYTOCHEMISTRY, 1981, 20 (04) : 811 - 814
[9] INGHARDT T, 1990, SYNTHESIS-STUTTGART, P285
[10] ISHIDA N, 1967, J ANTIBIOT, V20, P66

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