PLASTICITY IN THE AGING BRAIN - REVERSIBILITY OF ANATOMIC, METABOLIC, AND COGNITIVE DEFICITS IN NORMAL-PRESSURE HYDROCEPHALUS FOLLOWING SHUNT SURGERY

被引：30

作者：

KAYE, JA ^{[1
]}

GRADY, CL ^{[1
]}

HAXBY, JV ^{[1
]}

MOORE, A ^{[1
]}

FRIEDLAND, RP ^{[1
]}

机构：

[1] NIA,BRAIN AGING & DEMENTIA SECT,NEUROSCI LAB,BETHESDA,MD 20892

来源：

ARCHIVES OF NEUROLOGY | 1990年 / 47卷 / 12期

关键词：

D O I：

10.1001/archneur.1990.00530120082014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The course of idiopathic normal-pressure hydrocephalus was studied in a 78-year-old woman with a 4-year history of progressive dementia who underwent neuropsychologic testing, quantitative x-ray computed tomography, magnetic resonance imaging, and positron emission tomography with fludeoxyglucose F 18 to measure rates of regional cerebral glucose utilization. Preshunt cognitive testing demonstrated progressive deterioration during 2 years, and positron emission tomography showed significant reductions in regional cerebral glucose utilization of 34% to 49% as compared with age-and sex-matched control subjects in frontal, temporal, parietal, and whole brain regions. Periodic testing, carried out during a 2-year period after shunt surgery, showed steady improvement in clinical status. Parallel to the clinical changes, there was a significant reversal in neuropsychologic test scores with increased brain volume and increased regional cerebral glucose utilization in several brain regions. These results documented the considerable potential for recovery of compromised brain function in older subjects even after 4 years of progressive brain disease. © 1990, American Medical Association. All rights reserved.

引用

页码：1336 / 1341

页数：6

共 36 条

[1] SYMPTOMATIC OCCULT HYDROCEPHALUS WITH NORMAL CEREBROSPINAL-FLUID PRESSURE - A TREATABLE SYNDROME [J].

ADAMS, RD ;

FISHER, CM ;

HAKIM, S ;

OJEMANN, RG ;

SWEET, WH .

NEW ENGLAND JOURNAL OF MEDICINE, 1965, 273 (03) :117-&

[2]

BENTON AL, 1973, ASPECTOS PATOLOGICOS

[3]

BENTON AL, 1973, TEST FACIAL RECOGNIT

[4] ASSOCIATION BETWEEN QUANTITATIVE MEASURES OF DEMENTIA AND OF SENILE CHANGE IN CEREBRAL GREY MATTER OF ELDERLY SUBJECTS [J].

BLESSED, G ;

TOMLINSON, BE ;

ROTH, M .

BRITISH JOURNAL OF PSYCHIATRY, 1968, 114 (512) :797-+

[5] STUDIES ON CEREBRAL OXYGEN-METABOLISM, BLOOD-FLOW, AND BLOOD-VOLUME, IN PATIENTS WITH HYDROCEPHALUS BEFORE AND AFTER SURGICAL DECOMPRESSION, USING POSITRON EMISSION TOMOGRAPHY [J].

BROOKS, DJ ;

BEANEY, RP ;

POWELL, M ;

LEENDERS, KL ;

CROCKARD, HA ;

THOMAS, DGT ;

MARSHALL, J ;

JONES, T .

BRAIN, 1986, 109 :613-628

[6] SELECTIVE REMINDING FOR ANALYSIS OF MEMORY AND LEARNING [J].

BUSCHKE, H .

JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR, 1973, 12 (05) :543-550

[7] EXPERIMENTAL NORMAL-PRESSURE HYDROCEPHALUS IS ACCOMPANIED BY INCREASED TRANSMANTLE PRESSURE [J].

CONNER, ES ;

FOLEY, L ;

BLACK, PM .

JOURNAL OF NEUROSURGERY, 1984, 61 (02) :322-327

[8] COMPUTER-ASSISTED CATEGORIZATION OF BRAIN COMPUTERIZED-TOMOGRAPHY PIXELS INTO CEREBROSPINAL-FLUID, WHITE MATTER, AND GRAY-MATTER [J].

DELEO, JM ;

SCHWARTZ, M ;

CREASEY, H ;

CUTLER, N ;

RAPOPORT, SI .

COMPUTERS AND BIOMEDICAL RESEARCH, 1985, 18 (01) :79-88

[9] HUMAN-BRAIN GLUCOSE-UTILIZATION AND COGNITIVE FUNCTION IN RELATION TO AGE [J].

DUARA, R ;

GRADY, C ;

HAXBY, J ;

INGVAR, D ;

SOKOLOFF, L ;

MARGOLIN, RA ;

MANNING, RG ;

CUTLER, NR ;

RAPOPORT, SI .

ANNALS OF NEUROLOGY, 1984, 16 (06) :702-713

[10] HYDROCEPHALUS AS A CAUSE OF DISTURBANCES OF GAIT IN THE ELDERLY [J].

FISHER, CM .

NEUROLOGY, 1982, 32 (12) :1358-1363

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