EFFECTS OF ENDOTHELINS (ET-1, ET-2 AND ET-3) IN THE RABBIT EYE - ROLE OF PROSTAGLANDINS

被引:53
作者
GRANSTAM, E
WANG, L
BILL, A
机构
[1] Department of Physiology and Medical Biophysics, Uppsala University, Uppsala
关键词
ENDOTHELIN; INTRAOCULAR PRESSURE; BLOOD-AQUEOUS BARRIER; EYE (RABBIT); VASODILATATION; PROSTAGLANDINS;
D O I
10.1016/0014-2999(91)90108-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of intracameral injection of three endothelin isopeptides (ET-1, ET-2 and ET-3) were studied in the rabbit eye. All three peptides at pmol doses caused a dose-dependent rise in intraocular pressure (IOP) and an increase in protein concentration in the aqueous humor, indicating breakdown of the blood-aqueous barrier. Mean arterial blood pressure was not affected. ET-1 was more effective to increase IOP than were ET-2 and ET-3 whose effects seemed to be equal. ET-1 also caused vasodilation in the anterior uvea. The effects of ET-1, ET-2 and ET-3 on the IOP and blood-aqueous barrier, as well as the effects of ET-1 on regional blood flow in the eye, were abolished by pretreatment with indomethacin. Injection of 4 pmol ET-1 into the anterior chamber caused an increase in the concentration of prostaglandin E2 (PGE2) in the aqueous humor, most probably as a result of increased production of PGE2 in the anterior uvea. The results indicate that the effects of ET-1, ET-2 and ET-3 in the rabbit eye are to a large extent mediated by arachidonic acid metabolites.
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页码:217 / 223
页数:7
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