INTRACRANIAL TUBERCULOMAS - MRI SIGNAL INTENSITY CORRELATION WITH HISTOPATHOLOGY AND LOCALIZED PROTON SPECTROSCOPY

被引：88

作者：

GUPTA, RK

PANDEY, R

KHAN, EM

MITTAL, P

GUJRAL, RB

CHHABRA, DK

机构：

[1] MR Section, Department of Radiology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow

[2] Department of Pathology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow

[3] Department of Neurosurgery, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow

来源：

MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 03期

关键词：

BRAIN; TUBERCULOMA; MR; MR SPECTROSCOPY;

D O I：

10.1016/0730-725X(93)90079-S

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In seven cases of intracranial tuberculomas showing different signal intensities on MRI (five characteristic and two nonspecific), detailed histopathological examination was performed to look for number of macrophages, fibrosis, gliosis, degree of inflammatory cellular infiltrate, and type of caseation. The granulomas showing more macrophages, fibrosis and gliosis appeared hypointense on T2-weighted images. Tuberculomas showing minimal macrophages, marked cellular infiltration, and minimal fibrosis appeared hyperintense on T2-weighted images. Lesions showing similar signal intensity on T2-weighted images showed variation in the amount of macrophages, cellular infiltrates, maturity and fibrosis. Trace element estimation was done (iron, copper, and magnesium) in two of these lesions appearing hypointense on T2 and two normal brain samples; these were significantly lower in tuberculoma compared to normal brain tissue. Localised proton spectroscopy was performed in two hypointense lesions which showed marked increase in peaks in the region of mobile lipids (1.28 ppm) compared to normal brain parenchyma. It is concluded that the signal intensity of the lesions is dependent on the number of macrophages, fibrosis and cellular infiltrates. In addition increased lipid contents in the tuberculoma also contribute to the hypointensity on T2-weighted images.

引用

页码：443 / 449

页数：7

共 19 条

[1]

Gupta, Jena, Sharma, Guha, Khushu, Gupta, MR imaging of Intracranial tuberculoma, J. Comput. Assit. Tomogr., 12, 2, pp. 280-285, (1988)

[2]

Gupta, Jena, Singh, Sharma, Puri, Gupta, Role of MR in the diagnosis and management of intracranial tuberculomas, Clin. Radiol., 41, 2, pp. 120-127, (1990)

[3]

Chang, Han, Roh, Kim, Han, Choi, Et al., Gd-DTPA enhanced MR imaging in intracranial tuberculosis, Neuroradiol., 32, pp. 19-25, (1990)

[4]

Salgado, Del Brutto, Talamas, Zenteno, Carbajal, Intracranial tuberculoma MR imaging, Neuroradiol., 31, pp. 299-302, (1989)

[5]

Frahm, Bruhn, Gyngell, Merboldt, Hanicke, Sauter, Localised high resolution proton NMR spectroscopy using stimulated echoes: initial application to human brain in vivo, Magn. Reson. Med., 9, pp. 79-93, (1989)

[6]

Kreis, Farrow, Ross, Localised 1H NMR spectroscopy in patients with chronic hepaticencephalopathy. Analysis of changes in cerebral glutamine, choline and Inositols, NMR Biomed., 4, pp. 109-119, (1991)

[7]

Michaelis, Merboldt, Hanicke, Gyngell, Bruhn, Frahm, On the identification of cerebral metabolites in localised proton NMR spectra of the normal human brain in vivo, NMR Biomed., 4, pp. 90-98, (1991)

[8]

Dastur, Neurotuberculosis, Pathology of the Nervous System, 3, pp. 2412-2422, (1992)

[9]

Harrison, Netsky, Brown, Trace elements in human brain: Copper, zinc, iron, and magnesium, Clin. Chim. Acta, 21, pp. 55-60, (1968)

[10]

Marinier, High resolution NMR spectroscopy of cerebral white matter in multiple sclerosis, Magn. Reson. Med., 15, pp. 229-239, (1990)

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