DISSOLUTION SYSTEM FOR NIFEDIPINE SUSTAINED-RELEASE FORMULATIONS

被引：11

作者：

CHAUDHARY, RS

GANGWAL, SS

GUPTA, VK

SHAH, YN

JINDAL, KC

KHANNA, S

机构：

[1] Lupin Laboratories Limited, MIDC, Chikalthana, Aurangabad

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1994年 / 20卷 / 07期

关键词：

D O I：

10.3109/03639049409038366

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An in-vitro system for evaluating Nifedipine sustained release formulations has been developed. Two systems were evaluated to simulate sink conditions and correlate the system with flow through dissolution system in mechanism. For the purpose of evaluation two commercial brands were studied. The acidic biphasic system was found to be good for in-vitro dissolution rate evaluation of sustained release nifedipine tablets. It can be successfully utilized for routine quality control work.

引用

页码：1267 / 1274

页数：8

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