ANGIOGRAPHIC PROPERTIES OF GD-DTPA-24-CASCADE-POLYMER - A NEW MACROMOLECULAR MR CONTRAST AGENT

被引:37
作者
SCHWICKERT, HC [1 ]
ROBERTS, TPL [1 ]
MUHLER, A [1 ]
STISKAL, M [1 ]
DEMSAR, F [1 ]
BRASCH, RC [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT RADIOL,CONTRAST MEDIA LAB,SAN FRANCISCO,CA 94143
关键词
MAGNETIC RESONANCE (MR); ANGIOGRAPHY; CONTRAST MEDIA; MR; MACROMOLECULAR CONTRAST MEDIA;
D O I
10.1016/0720-048X(95)00645-7
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: A new macromolecular MR contrast agent, Gd-DTPA-24-cascade-polymer, was assessed for MR angiography of peritumoral vessels in rats. Material and methods: High resolution 3D-SPGR (TR/TE 100/5ms, alpha = 90 degrees) angiograms were acquired in 10 Fischer rats bearing subcutaneous R3230 mammary adenocarcinomas. MRI was performed before, immediately and 40 min after administration of Gd-DTPA (0.1 mmol Gd/kg), and after either Gd-DTPA-cascade-polymer or albumin-(Gd-DTPA)(30) (each 0.05 mmol Gd/kg). A semi-quantitative analysis of small peritumoral vessels and tumor rim enhancement was performed on maximum intensity projection (MIP) angiograms using a 4-point scoring system. A quantitative analysis compared vascular signal-to-background-(S/B), signal-to-noise-, and contrast-to-noise-ratio. Results: Gd-DTPA produced a transient and low-scoring vessel definition (0.2 +/- 0.1), but strong rim enhancement (score 1.7 +/- 0.1). The cascade polymer resulted in better but submaximal vessel delineation (score 1.6 +/- 0.3, S/B 5.0 +/- 0.2) and strong rim enhancement (score 1.8 +/- 0.1). Albumin-(Gd-DTPA)(30) produced the best and most time-persistent angiograms (score 2.6 +/- 0.2, S/B 7.4 +/- 0.2), but minimal rim enhancement (score 0.3 +/- 0.2). Conclusion: The Gd-DTPA-24-cascade-polymer demonstrated the useful combination of strong tumor rim enhancement and detailed angiographic definition of peritumoral vessels. These are advantages associated with extracellular and blood pool contrast media, respectively.
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页码:144 / 150
页数:7
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