ANGIOGRAPHIC PROPERTIES OF GD-DTPA-24-CASCADE-POLYMER - A NEW MACROMOLECULAR MR CONTRAST AGENT

被引：37

作者：

SCHWICKERT, HC ^{[1
]}

ROBERTS, TPL ^{[1
]}

MUHLER, A ^{[1
]}

STISKAL, M ^{[1
]}

DEMSAR, F ^{[1
]}

BRASCH, RC ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT RADIOL,CONTRAST MEDIA LAB,SAN FRANCISCO,CA 94143

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 1995年 / 20卷 / 02期

关键词：

MAGNETIC RESONANCE (MR); ANGIOGRAPHY; CONTRAST MEDIA; MR; MACROMOLECULAR CONTRAST MEDIA;

D O I：

10.1016/0720-048X(95)00645-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: A new macromolecular MR contrast agent, Gd-DTPA-24-cascade-polymer, was assessed for MR angiography of peritumoral vessels in rats. Material and methods: High resolution 3D-SPGR (TR/TE 100/5ms, alpha = 90 degrees) angiograms were acquired in 10 Fischer rats bearing subcutaneous R3230 mammary adenocarcinomas. MRI was performed before, immediately and 40 min after administration of Gd-DTPA (0.1 mmol Gd/kg), and after either Gd-DTPA-cascade-polymer or albumin-(Gd-DTPA)(30) (each 0.05 mmol Gd/kg). A semi-quantitative analysis of small peritumoral vessels and tumor rim enhancement was performed on maximum intensity projection (MIP) angiograms using a 4-point scoring system. A quantitative analysis compared vascular signal-to-background-(S/B), signal-to-noise-, and contrast-to-noise-ratio. Results: Gd-DTPA produced a transient and low-scoring vessel definition (0.2 +/- 0.1), but strong rim enhancement (score 1.7 +/- 0.1). The cascade polymer resulted in better but submaximal vessel delineation (score 1.6 +/- 0.3, S/B 5.0 +/- 0.2) and strong rim enhancement (score 1.8 +/- 0.1). Albumin-(Gd-DTPA)(30) produced the best and most time-persistent angiograms (score 2.6 +/- 0.2, S/B 7.4 +/- 0.2), but minimal rim enhancement (score 0.3 +/- 0.2). Conclusion: The Gd-DTPA-24-cascade-polymer demonstrated the useful combination of strong tumor rim enhancement and detailed angiographic definition of peritumoral vessels. These are advantages associated with extracellular and blood pool contrast media, respectively.

引用

页码：144 / 150

页数：7

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