ENGINEERING PATHWAYS FOR TRANSFORMATIONS OF MORPHINE ALKALOIDS

被引：19

作者：

BRUCE, NC

FRENCH, CE

HAILES, AM

LONG, MT

RATHBONE, DA

机构：

[1] The Institute of Biotechnology, University of Cambridge, Cambridge, CB2 1QT, Tennis Court Road

来源：

TRENDS IN BIOTECHNOLOGY | 1995年 / 13卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0167-7799(00)88946-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Semisynthetic opiates provide some of the most potent analgesic compounds currently in clinical use, the majority of which are synthesized from the naturally occurring alkaloids morphine, codeine and thebaine. The use of recombinant DNA technology to engineer pathways for the biological synthesis of semisynthetic opiate drugs could offer significant advantages over existing chemical methods and may, ultimately, provide novel biosynthetic routes for the development of new therapeutics.

引用

收藏

页码：200 / 205

页数：6

相关论文

共 19 条

[1] TOWARDS ENGINEERING PATHWAYS FOR THE SYNTHESIS OF ANALGESICS AND ANTITUSSIVES [J].

BRUCE, NC ;

CASWELL, DA ;

FRENCH, CE ;

HAILES, AM ;

LONG, MT ;

WILLEY, DL .

RECOMBINANT DNA TECHNOLOGY II, 1994, 721 :85-99

[2] MICROBIAL-DEGRADATION OF THE MORPHINE ALKALOIDS - PURIFICATION AND CHARACTERIZATION OF MORPHINE DEHYDROGENASE FROM PSEUDOMONAS-PUTIDA M10 [J].

BRUCE, NC ;

WILMOT, CJ ;

JORDAN, KN ;

STEPHENS, LDG ;

LOWE, CR .

BIOCHEMICAL JOURNAL, 1991, 274 :875-880

[3] MICROBIAL-DEGRADATION OF THE MORPHINE ALKALOIDS - IDENTIFICATION OF MORPHINONE AS AN INTERMEDIATE IN THE METABOLISM OF MORPHINE BY PSEUDOMONAS-PUTIDA M10 [J].

BRUCE, NC ;

WILMOT, CJ ;

JORDAN, KN ;

TREBILCOCK, AE ;

STEPHENS, LDG ;

LOWE, CR .

ARCHIVES OF MICROBIOLOGY, 1990, 154 (05) :465-470

[4] IDENTIFICATION OF A HEROIN ESTERASE IN RHODOCOCCUS SP STRAIN H1 [J].

CAMERON, GWW ;

JORDAN, KN ;

HOLT, PJ ;

BAKER, PB ;

LOWE, CR ;

BRUCE, NC .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1994, 60 (10) :3881-3883

[5] PURIFICATION AND CHARACTERIZATION OF MORPHINONE REDUCTASE FROM PSEUDOMONAS-PUTIDA M10 [J].

FRENCH, CE ;

BRUCE, NC .

BIOCHEMICAL JOURNAL, 1994, 301 :97-103

[6]

FRENCH CE, IN PRESS BIOTECHNOLO

[7] BIOLOGICAL SYNTHESIS OF THE ANALGESIC HYDROMORPHONE, AN INTERMEDIATE IN THE METABOLISM OF MORPHINE, BY PSEUDOMONAS-PUTIDA M10 [J].

HAILES, AM ;

BRUCE, NC .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1993, 59 (07) :2166-2170

[8]

HOLT PJ, IN PRESS BIOSENS BIO

[9]

IIZUKA K, 1962, CHEM PHARM BULL, V10, P67

[10]

Iizuka K., 1960, CHEM PHARM BULL, V8, P1056