EPIDERMAL GROWTH-FACTOR RECEPTORS AND PROGNOSIS IN PRIMARY BREAST-CANCER

被引:49
作者
SPYRATOS, F
DELARUE, JC
ANDRIEU, C
LIDEREAU, R
CHAMPEME, MH
HACENE, K
BRUNET, M
机构
[1] CTR RENE HUGUENIN,ONCOVIROL LAB,F-92211 ST CLOUD,FRANCE
[2] CTR RENE HUGUENIN,DEPT STAT MED,F-92211 ST CLOUD,FRANCE
[3] CTR RENE HUGUENIN,DEPT CHIRURG,F-92211 ST CLOUD,FRANCE
[4] INST GUSTAVE ROUSSY,F-94800 VILLEJUIF,FRANCE
关键词
BREAST CANCER; PROGNOSIS; EPIDERMAL GROWTH FACTOR RECEPTOR;
D O I
10.1007/BF01806288
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A retrospective study was performed on 109 human breast tumors stored in liquid nitrogen in order to assess the prognostic value of epidermal growth factor receptor (EGF-R) (median patient follow-up 5 years). A significant inverse relationship was observed between EGF-R and both estrogen (ER) and progesterone receptors (PR). Univariate analysis showed a trend towards a shorter metastasis-free survival both in the overall population and in node-negative patients with EGF-R positive tumors. Multivariate analysis of the overall population showed that lymph-node involvement and PR status were the only significant variables in predicting metastasis-free survival. However, in patients receiving no adjuvant treatment (hormone therapy or chemotherapy), EGF was the only significant variable in the multivariate Cox analysis. No c-erbB-1 amplification was detected in these tumors.
引用
收藏
页码:83 / 89
页数:7
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