ABSENCE OF THE C-HA-RAS CODON 61 POINT MUTATION IN MURINE SOLID TUMORS INDUCED BY SUBCUTANEOUSLY APPLIED 7,12-DIMETHYLBENZANTHRACENE

被引：8

作者：

ANDREWS, DF

COLLINS, SJ

REDDY, AL

机构：

[1] FRED HUTCHINSON CANC RES CTR,MOLEC MED PROGRAM,SEATTLE,WA 98104

[2] UNIV WASHINGTON,DEPT MED,DIV ONCOL,SEATTLE,WA 98195

[3] UNIV WASHINGTON,DEPT MED,DIV MED GENET,SEATTLE,WA 98195

来源：

CANCER LETTERS | 1990年 / 54卷 / 03期

关键词：

fibrosarcoma; phosphoglycerate kinase; RFLP;

D O I：

10.1016/0304-3835(90)90035-V

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The c-Ha-ras-1 codon 61 A→T transversion is a highly consistent finding in murine skin DMBA-initiated/TPA-promoted papillomas and carcinomas. We performed Xba I RFLP analysis on DNA from clonal cell lines derived from 11 independent papillomas and a single carcinoma derived from topically applied DMBA and compared this to RFLP on DNA from 7 clonal fibrosarcoma cell lines derived from tumors arising after subcutaneous administration of the same carcinogen. The A→T point mutation was present in all of the papillomas and carcinoma derived by the classic DMBA-TPA protocol but was absent in all of the fibrosarcomas arising after subcutaneous administration of DMBA. © 1990.

引用

页码：139 / 145

页数：7

共 25 条

[1] MOUSE SKIN CARCINOMAS INDUCED INVIVO BY CHEMICAL CARCINOGENS HAVE A TRANSFORMING HARVEY-RAS ONCOGENE [J].

BALMAIN, A ;

PRAGNELL, IB .

NATURE, 1983, 303 (5912) :72-74

[2] ONCOGENE ACTIVATION IN CHEMICAL CARCINOGENESIS [J].

BALMAIN, A ;

BROWN, K .

ADVANCES IN CANCER RESEARCH, 1988, 51 :147-182

[3] MUTAGENESIS OF THE HA-RAS ONCOGENE IN MOUSE SKIN TUMORS INDUCED BY POLYCYCLIC AROMATIC-HYDROCARBONS [J].

BIZUB, D ;

WOOD, AW ;

SKALKA, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (16) :6048-6052

[4] RAS (PROTO)ONCOGENE INDUCES N-LINKED CARBOHYDRATE MODIFICATION - TEMPORAL RELATIONSHIP WITH INDUCTION OF INVASIVE POTENTIAL [J].

BOLSCHER, JGM ;

VANDERBIJL, MMW ;

NEEFJES, JJ ;

HALL, A ;

SMETS, LA ;

PLOEGH, HL .

EMBO JOURNAL, 1988, 7 (11) :3361-3368

[5]

BOUTWELL RK, 1964, PROG EXP TUMOR RES, V4, P207

[6] THE CYTOPLASMIC PROTEIN GAP IS IMPLICATED AS THE TARGET FOR REGULATION BY THE RAS GENE-PRODUCT [J].

CALES, C ;

HANCOCK, JF ;

MARSHALL, CJ ;

HALL, A .

NATURE, 1988, 332 (6164) :548-551

[7] HUMAN GENOME CONTAINS 4 GENES HOMOLOGOUS TO TRANSFORMING GENES OF HARVEY AND KIRSTEN MURINE SARCOMA-VIRUSES [J].

CHANG, EH ;

GONDA, MA ;

ELLIS, RW ;

SCOLNICK, EM ;

LOWY, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (16) :4848-4852

[8] SPECIFIC ACTIVATION OF THE CELLULAR HARVEY-RAS ONCOGENE IN DIMETHYLBENZANTHRACENE-INDUCED MOUSE MAMMARY-TUMORS [J].

DANDEKAR, S ;

SUKUMAR, S ;

ZARBL, H ;

YOUNG, LJT ;

CARDIFF, RD .

MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (11) :4104-4108

[9] FREQUENT ACTIVATION OF C-KIS AS A TRANSFORMING GENE IN FIBROSARCOMAS INDUCED BY METHYLCHOLANTHRENE [J].

EVA, A ;

AARONSON, SA .

SCIENCE, 1983, 220 (4600) :955-956

[10] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

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