INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND IGF-BINDING PROTEINS BOTH DECLINE IN THE RAT DURING LATE PREGNANCY

被引：54

作者：

GARGOSKY, SE ^{[1
]}

WALTON, PE ^{[1
]}

OWENS, PC ^{[1
]}

WALLACE, JC ^{[1
]}

BALLARD, FJ ^{[1
]}

机构：

[1] CSIRO,DIV HUMAN NUTR,ADELAIDE,SA 5000,AUSTRALIA

来源：

JOURNAL OF ENDOCRINOLOGY | 1990年 / 127卷 / 03期

关键词：

D O I：

10.1677/joe.0.1270383

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-like growth factor-I (IGF-I), IGF-II and IGF-binding proteins (IGFBP) were examined in rat serum during pregnancy and lactation. IGF-I concentrations determined after acid column chromatography of serum were low during the last third of pregnancy. IGF-II was undetectable in pregnant and non-pregnant rats. IGF-binding protein (IGFBP) concentrations, measured as high molecular mass activity in the IGF-I RIA and the IGF-II RRA of acid column fractions, paralleled the changes observed with IGF-I. Western ligand blot analysis of serum from non-pregnant rats revealed a 40-50 kDa IGFBP aligning with IGFBP-3, a smaller 28-30 kDa doublet and 24 kDa IGFBP. Serum from rats in late pregnancy lacked IGFBP-3, whereas the smaller IGFBP persisted during late pregnancy. IGFBP-3 reappeared in postpartum animals. The fall in serum IGF-I is consistent with a maternal catabolic state during late pregnancy which may maximize substrate availability for the developing fetus.

引用

页码：383 / 390

页数：8

共 37 条

[1]

BALLARD F, 1990, ACTA ENDOCRINOL-COP, V121, P751

[2] BINDING-PROPERTIES AND BIOLOGICAL POTENCIES OF INSULIN-LIKE GROWTH-FACTORS IN L6 MYOBLASTS [J].