AN UNIDENTIFIED MACROMOLECULAR INHIBITORY CONSTITUENT OF CALCIUM-OXALATE CRYSTAL-GROWTH IN HUMAN URINE

被引：42

作者：

SORENSEN, S ^{[1
]}

HANSEN, K ^{[1
]}

BAK, S ^{[1
]}

JUSTESEN, SJ ^{[1
]}

机构：

[1] HERLEV HOSP,DEPT CLIN CHEM,DK-2730 HERLEV,DENMARK

来源：

UROLOGICAL RESEARCH | 1990年 / 18卷 / 06期

关键词：

Calcium oxalate; Glycosaminoglycans; Growth inhibitors; Proteins; Urine; Urine calculi;

D O I：

10.1007/BF00297368

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We have detected and isolated a macromolecular constituent in normal human urine possessing calcium crystal growth inhibitory activity. The purification procedure consisted of two anion exchange chromatographies and one affinity chromatography. The crystal growth inhibitor was found to be heterogeneous in net charge as well as in size. It has not been identified. It is not an uronic acid-containing glycosaminoglycan, hitherto presumed to be responsible for the inhibitory activity. Whether an urinary fragment of inter-α-trypsin inhibitor is responsible has yet to be resolved. © 1990 Springer-Verlag.

引用

页码：373 / 379

页数：7

共 29 条

[1] NEW METHOD FOR QUANTITATIVE-DETERMINATION OF URONIC ACIDS [J].