REDUCED VASCULAR COMPLIANCE AS A MARKER FOR ESSENTIAL-HYPERTENSION

被引：117

作者：

MCVEIGH, GE ^{[1
]}

BURNS, DE ^{[1
]}

FINKELSTEIN, SM ^{[1
]}

MCDONALD, KM ^{[1
]}

MOCK, JE ^{[1
]}

FESKE, W ^{[1
]}

CARLYLE, PF ^{[1
]}

FLACK, J ^{[1
]}

GRIMM, R ^{[1
]}

COHN, JN ^{[1
]}

机构：

[1] UNIV MINNESOTA,SCH MED,DEPT MED,DIV CARDIOVASC,MINNEAPOLIS,MN 55455

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 03期

关键词：

HYPERTENSION; VASCULAR COMPLIANCE; VASCULAR RESISTANCE; PULSE CONTOUR ANALYSIS;

D O I：

10.1093/ajh/4.3.245

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In 38 patients with established essential hypertension and 32 age-matched normotensive control subjects proximal and distal arterial compliance were determined by computer-based assessment of the diastolic decay of a brachial arterial tracing and a modified Windkessel model of the circulation. In the hypertensive subjects compared to the normotensive subjects mean arterial pressure was 25% higher (P < .001), systemic vascular resistance 23% higher (P < .01), proximal compliance 19% lower (P < .01), and distal compliance 72% lower (P < .001). The reduction in distal compliance was highly age-dependent. In the youngest age range (45 to 54 years) little overlap appeared between hypertensive and normotensive groups, whereas in the oldest subjects studied (65 to 75 years) distal compliance was comparably low in the two groups. Thus, distal vascular compliance provides a sensitive and specific marker for the abnormal vasculature associated with hypertension and may be particularly useful in identifying the disease in young individuals with borderline blood pressure.

引用

页码：245 / 251

页数：7

共 37 条

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