DAMAGE TO MITOCHONDRIAL RESPIRATION CHAIN IS RELATED TO PHOSPHOLIPASE-A2 ACTIVATION CAUSED BY TUMOR-NECROSIS-FACTOR

被引：23

作者：

HIGUCHI, M ^{[1
]}

SHIROTANI, K ^{[1
]}

HIGASHI, N ^{[1
]}

TOYOSHIMA, S ^{[1
]}

OSAWA, T ^{[1
]}

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, DIV CHEM TOXICOL & IMMUNOCHEM, TOKYO 113, JAPAN

来源：

JOURNAL OF IMMUNOTHERAPY | 1992年 / 12卷 / 01期

关键词：

MITOCHONDRIAL RESPIRATION; PHOSPHOLIPASE-A2; TUMOR NECROSIS FACTOR;

D O I：

10.1097/00002371-199207000-00005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor necrosis factor (TNF) has been shown to be cytotoxic to tumor cell lines in vitro, but the mechanism by which TNF exerts its cell growth-regulatory effects is not known. In this report, we used various inhibitors to investigate the sequence of events that lead to cytotoxic effects of TNF on L.P3 cells, a highly sensitive, murine fibroblast cell line. Our results indicate that mitochondrial respiration chains are damaged by a hydroxyl radical at an early stage of the cell lysis after TNF treatment. This event is followed by the activation of phospholipase A2, and finally leads to cell lysis.

引用

页码：41 / 49

页数：9

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