CELL BIOLOGICAL FACTORS ASSOCIATED WITH THE RESPONSE OF BREAST-CANCER TO SYSTEMIC TREATMENT

被引:54
作者
KLIJN, JGM
BERNS, EMJJ
BONTENBAL, M
FOEKENS, J
机构
[1] Division of Endocrine Oncology, Department of Medical Oncology, Rotterdam Cancer Institute (Dr Daniel den Hoed Cancer Center)
关键词
D O I
10.1016/0305-7372(93)90007-E
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A large number of cell biological parameters are currently available to predict the prognosis of patients with breast cancer, but it is still difficult accurately to predict the response to treatment. A valuable prognostic factor can be a poor predictive factor for response, and vice versa. High tumor levels of ER, PgR, AR and pS2 predict a relatively good response to endocrine therapy, while EGF-R positivity, HER2/neu positivity, aneuploidy, high proliferation indices and possibly high uPA levels indicate a high chance of poor response to endocrine therapy in metastatic breast cancer. With respect to chemotherapy, a high proliferation rate and H ER2/neu amplification predict a good response to therapy in metastatic disease, while MDR gene expression and possibly c-myc amplification are related to a worse response. In conclusion, the newer cell biological parameters can be used to select high and low-risk patients, type of systemic treatment, and as targets for new treatment modalities. © 1993.
引用
收藏
页码:45 / 63
页数:19
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共 116 条
[1]  
ALEXIEVAFIGUSCH J, 1988, CANCER-AM CANCER SOC, V61, P758, DOI 10.1002/1097-0142(19880215)61:4<758::AID-CNCR2820610421>3.0.CO
[2]  
2-T
[3]   HER-2/NEU IN NODE-NEGATIVE BREAST-CANCER - PROGNOSTIC-SIGNIFICANCE OF OVEREXPRESSION INFLUENCED BY THE PRESENCE OF INSITU CARCINOMA [J].
ALLRED, DC ;
CLARK, GM ;
TANDON, AK ;
MOLINA, R ;
TORMEY, DC ;
OSBORNE, CK ;
GILCHRIST, KW ;
MANSOUR, EG ;
ABELOFF, M ;
EUDEY, L ;
MCGUIRE, WL .
JOURNAL OF CLINICAL ONCOLOGY, 1992, 10 (04) :599-605
[4]  
BAKKER GH, 1989, ENDOCRINOLOGY, V125, P1593, DOI 10.1210/endo-125-3-1593
[5]  
BERNS PMJ, 1992, CANCER RES, V52, P1036
[6]  
BERNS PMJ, 1992, CANCER RES, V52, P1107
[7]  
BERNS PMJ, 1991, 5TH EORTC BREAST CAN
[8]  
BERNS PMJ, 1992, EUR J CANCER, V28, P697
[9]  
BERNS PMJ, 1992, J STEROID BIOCH MOL, V43, P13
[10]  
BONNETERRE J, 1990, CANCER RES, V50, P6931