THE NUDE-MOUSE AS AN INVIVO MODEL FOR HUMAN BREAST-CANCER INVASION AND METASTASIS

被引：28

作者：

BRUNNER, N

BOYSEN, B

ROMER, J

SPANGTHOMSEN, M

机构：

[1] RIGSHOSP,FINSEN LAB,DK-2100 COPENHAGEN,DENMARK

[2] UNIV COPENHAGEN,INST PATHOL ANAT,DK-1168 COPENHAGEN,DENMARK

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1993年 / 24卷 / 03期

关键词：

GENETIC LABELING; LACZ TRANSFECTANTS; METASTASIS MODELS; MICROMETASTASIS DETECTION; NUDE MICE;

D O I：

10.1007/BF01833265

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human breast cancer xenografts only rarely invade and metastasize in nude mice. and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient mice in terms of providing a model for studies of the invasive and metastatic capability of human breast cancer xenografts. Genetic labelling of human cancer cells with the lacZ gene is described as a specific and highly sensitive method for identification of micrometastases in such a model.

引用

页码：257 / 264

页数：8

共 28 条

[1] ALBINI A, 1987, CANCER RES, V47, P3239
[2] A NOVEL METALLOPROTEINASE GENE SPECIFICALLY EXPRESSED IN STROMAL CELLS OF BREAST CARCINOMAS
BASSET, P
BELLOCQ, JP
WOLF, C
STOLL, I
HUTIN, P
LIMACHER, JM
PODHAJCER, OL
CHENARD, MP
RIO, MC
CHAMBON, P
[J]. NATURE, 1990, 348 (6303) : 699 - 704
[3] ENDOCRINE THERAPY OF HUMAN-BREAST CANCER GROWN IN NUDE-MICE
BRUNNER, N
OSBORNE, CK
SPANGTHOMSEN, M
[J]. BREAST CANCER RESEARCH AND TREATMENT, 1987, 10 (03) : 229 - 242
[4] LACZ TRANSDUCED HUMAN BREAST-CANCER XENOGRAFTS AS AN INVIVO MODEL FOR THE STUDY OF INVASION AND METASTASIS
BRUNNER, N
THOMPSON, EW
SPANGTHOMSEN, M
RYGAARD, J
DANO, K
ZWIEBEL, JA
[J]. EUROPEAN JOURNAL OF CANCER, 1992, 28A (12) : 1989 - 1995
[5] BRUNNER N, IN PRESS CANCER RES
[6] THE INTER-RELATIONSHIPS BETWEEN OVARIAN-INDEPENDENT GROWTH, TUMORIGENICITY, INVASIVENESS AND ANTIOESTROGEN RESISTANCE IN THE MALIGNANT PROGRESSION OF HUMAN-BREAST CANCER
CLARKE, R
BRUNNER, N
THOMPSON, EW
GLANZ, P
KATZ, D
DICKSON, RB
LIPPMAN, ME
[J]. JOURNAL OF ENDOCRINOLOGY, 1989, 122 (01) : 331 - 340
[7] PROGRESSION OF HUMAN-BREAST CANCER-CELLS FROM HORMONE-DEPENDENT TO HORMONE-INDEPENDENT GROWTH BOTH INVITRO AND INVIVO
CLARKE, R
BRUNNER, N
KATZENELLENBOGEN, BS
THOMPSON, EW
NORMAN, MJ
KOPPI, C
PAIK, S
LIPPMAN, ME
DICKSON, RB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (10) : 3649 - 3653
[8] PLASMINOGEN ACTIVATORS, TISSUE DEGRADATION, AND CANCER
DANO, K
ANDREASEN, PA
GRONDAHLHANSEN, J
KRISTENSEN, P
NIELSEN, LS
SKRIVER, L
[J]. ADVANCES IN CANCER RESEARCH, 1985, 44 : 139 - 266
[9] FRANDSEN TL, 1992, FIBRINOLYSIS, V6, P71
[10] ALTERATION OF THE TUMORIGENIC AND METASTATIC PROPERTIES OF NEOPLASTIC-CELLS IS ASSOCIATED WITH THE PROCESS OF CALCIUM PHOSPHATE-MEDIATED DNA TRANSFECTION
KERBEL, RS
WAGHORNE, C
MAN, MS
ELLIOTT, B
BREITMAN, ML
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) : 1263 - 1267

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