COMBINATORIALLY SELECTED GUANOSINE-QUARTET STRUCTURE IS A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS ENVELOPE-MEDIATED CELL-FUSION

被引：285

作者：

WYATT, JR

VICKERS, TA

ROBERSON, JL

BUCKHEIT, RW

KLIMKAIT, T

DEBAETS, E

DAVIS, PW

RAYNER, B

IMBACH, JL

ECKER, DJ

机构：

[1] SO RES INST, FREDERICK, MD 21701 USA

[2] CIBA GEIGY AG, PHARMACEUT RES, BASEL, SWITZERLAND

[3] UNIV MONTPELLIER 2, CHIM BIOORGAN LAB, F-34095 MONTPELLIER 5, FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 04期

关键词：

PHOSPHOROTHIOATE; OLIGONUCLEOTIDE; GP120; V3; LOOP; RANDOM LIBRARIES;

D O I：

10.1073/pnas.91.4.1356

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The phosphorothioate oligonucleotide T(2)G(4)T(2) was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained all possible octanucleotide sequences. The oligonucleotide forms a parallel-stranded tetrameric guanosine-quartet structure. Tetramer formation and the phosphorothioate backbone are essential for antiviral activity. The tetramer binds to the human immunodeficiency virus envelope protein gp120 at the V3 loop and inhibits both cell to-cell and virus-to cell infection.

引用

页码：1356 / 1360

页数：5

共 38 条

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