AUTOMETALLOGRAPHIC DETECTION OF SILVER IN HYPOTHALAMIC NEURONS OF RATS EXPOSED TO SILVER-NITRATE

被引：9

作者：

STOLTENBERG, M

JUHL, S

POULSEN, EH

ERNST, E

机构：

[1] Department of Neurobiology, Institute of Anatomy, University of Aarhus, Århus

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1994年 / 14卷 / 04期

关键词：

SILVER; HEAVY METALS; AUTOMETALLOGRAPHY; BRAIN; HYPOTHALAMUS; NEURONS; RAT;

D O I：

10.1002/jat.2550140406

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The silver amplification technique, autometallography, has been used to reveal silver accumulation in neurons in the hypothalamus of male Wistar-Kyoto rats. Silver penetrated the blood-brain barrier after exposure to silver nitrate, and differences in staining intensity were found between the hypothalamic nuclei. When using light microscopy, the silver staining of the hypothalamic neurons was highly heterogeneous. Silver was detected exclusively in lysosomes of the loaded neurons. Aspects of this heterogeneous localization are discussed in relation to the distribution of autometallographically developed gold and mercury.

引用

页码：275 / 280

页数：6

共 32 条

[1] ARGYRIA - TISSUE DEPOSITION OF SILVER AS SELENIDE [J].