EFFECT OF PERINATAL LEAD-EXPOSURE ON MORPHINE-TOLERANCE IN THE NEONATAL RAT

被引：3

作者：

KITCHEN, I

BOSWELL, JA

机构：

[1] Department of Biochemistry, Molecular Toxicology and Pharmacology Group, University of Surrey

来源：

TOXICOLOGY LETTERS | 1990年 / 54卷 / 01期

关键词：

Antinociception; Lead neurotoxicity; Morphine tolerance; Ontogeny;

D O I：

10.1016/0378-4274(90)90062-Q

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Administration of lead (at 300 and 1000 ppm) in the maternal drinking water from conception to postnatal day 10 increased the sensitivity of 10-day rat pups to noxious stimuli and disrupted the dose-response relationship to morphine antinociception. Lead-exposed rats could be made tolerant to morphine over a 5-day period (twice daily injections of 5 mg/kg morphine, postnatal days 5-10) and antinociceptive responses in tolerant rats were also disrupted by lead exposure. © 1990.

引用

页码：107 / 112

页数：6

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